Results 51 to 60 of about 830,136 (276)

The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study [PDF]

, 2009
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection ...
Helber Uwe, Schroeder Stephen, Aebert Hermann, Burgstahler Christof, Usta Engin, Kopp Andreas F, Ziemer Gerhard   +6 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease [PDF]

, 2008
peer reviewedMolecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it ...
A. Winkeler, Y. Waerzeggers, A. Klose, P. Monfared, A. V. Thomas, M. Schubert, M. T. Heneka, A. H. Jacobs, I Grundke-Iqbal, DJ Selkoe, A Goate, E Levy-Lahad, EI Rogaev, R Sherrington, M Mullan, GA Higgins, K Hsiao, C Sturchler-Pierrat, D Games, K Duff, L Holcomb, WD Heiss, WD Heiss, K Herholz, DH Silverman, S Minoshima, EM Reiman, M Iyo, K Herholz, H Namba, H Shinotoh, JO Rinne, BJ Bacskai, WE Klunk, CA Mathis, WE Klunk, ED Agdeppa, K Shoghi-Jadid, H Toyama, WE Klunk, WE Klunk, E McGowan, M Schubert, MT Heneka   +43 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Developments in Non-Invasive Imaging to Guide Diagnosis and Treatment of Proliferative Diabetic Retinopathy: A Systematic Review

International Journal of Translational Medicine, 2021
Diagnosis and management of proliferative diabetic retinopathy are reliant upon retinal imaging. A systematic literature review of non-invasive imaging to guide diagnosis and treatment of proliferative diabetic retinopathy was performed. There is a trend
Ellie Bowditch, Andrew Chang, Hemal Mehta   +2 more
doaj   +1 more source

Three Dimensional Electrical Impedance Tomography [PDF]

, 1996
The electrical resistivity of mammalian tissues varies widely and is correlated with physiological function. Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a non-invasive means of imaging the internal ...
A Albert, AM Dijkstra, B. H. Brown, BH Brown, BH Brown, CJ Kotre, D. C. Barber, DA Witsoe, DB Geselowitz, DC Barber, DC Barber, DC Barber, DC Barber, DC Barber, DS Holder, ET McAdams, FA Duck, GH Golub, J Goble, JP Morucci, KS Rabbani, LA Geddes, P. Metherall, PC Hansen, R Pethig, R. H. Smallwood, RD Stoy, SG Dawids   +27 more
core   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, EarlyView.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Tip-gating Effect in Scanning Impedance Microscopy of Nanoelectronic Devices

, 2002
Electronic transport in semiconducting single-wall carbon nanotubes is studied by combined scanning gate microscopy and scanning impedance microscopy (SIM).
Bonnell, Dawn A., Freitag, Marcus, Johnson, A. T., Kalinin, Sergei V.   +3 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multifunctional Nanoparticles for Imaging Guided Interventions [PDF]

, 2008
We describe multifunctional magnetic nanoparticles (MNPs) encapsulated in thermosensitive, drug-bearing shells and delivered to the tumor site by genetically modified and non-pathogenic strains of bacteria with known affinity to tumors for an effective ...
Basel al-Ramadi, Bashar Issa, Hassan Hijaze, Saleh Hayek, Shahnaz Qadri, Yousef Haik   +5 more
core   +1 more source