Results 71 to 80 of about 830,136 (276)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Patient-reported outcomes and home-based self-swabs for influenza-like illness events - lessons learned from the 2023/2024 DANFLU-2 Homeswab PRO substudy

Journal of Patient-Reported Outcomes
Background Self-swabs and digital patient-reported outcomes (PROs) offer innovative tools for decentralized monitoring of infectious diseases. The DANFLU-2 HomeSwab PRO substudy evaluated the feasibility of using these methods for tracking influenza-like
Filip Soeskov Davidovski, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Daniel Modin, Nabila Shaikh, Jose Bartelt-Hofer, Matthew M. Loiacono, Rebecca C. Harris, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Randi Jessen, Nina Steenhard, Brian L. Claggett, Scott D. Solomon, Lars Køber, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Tor Biering-Sørensen   +20 more
doaj   +1 more source

High-sensitivity C-reactive protein is associated with altered cardiac structure and function in psoriasis: The PSOCADIA study

International Journal of Cardiology: Heart & Vasculature
Background: High sensitivity C-reactive protein (hsCRP) is a biomarker of systemic inflammation that may be associated with cardiovascular risk in psoriasis.
Maria Dons, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Mats C.H. Lassen, Sofie Bøgh-Sørensen, Julie I.H. Borchsenius, Filip Soeskov Davidovski, Nino E. Landler, Christoffer V. Nissen, Peter Riis Hansen, Brittany N. Weber, Claus Zachariae, Lone Skov, Tor Biering-Sørensen   +14 more
doaj   +1 more source

Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia [PDF]

, 2018
Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate.
Gresits, I., Gyüre-Garami, B., Márkus, B. G., Simon, F., Sági, O., Thuróczy, Gy.   +5 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Non invasive subsurface imaging to investigate the site evolution of Machu Picchu

Scientific Reports, 2023
The construction history of a site is partially preserved underground and can be revealed through archaeological investigations, including excavations, integrated with earth observation (EO) methods and technologies that make it possible to overcome some
Nicola Masini, Gerardo Romano, Dominika Sieczkowska, Luigi Capozzoli, Daniele Spizzichino, Francesco Gabellone, Jose Bastante, Manuela Scavone, Maria Sileo, Nicodemo Abate, Claudio Margottini, Rosa Lasaponara   +11 more
doaj   +1 more source

An evaluation of morphological and functional multi-parametric MRI sequences in classifying non-muscle and muscle invasive bladder cancer [PDF]

, 2017
Objectives: Our goal is to determine the ability of multi-parametric magnetic resonance imaging (mpMRI) to differentiate muscle invasive bladder cancer (MIBC) from non-muscle invasive bladder cancer (NMIBC).
Barchetti, Giovanni, Carano, Davide, Catalano, Carlo, Catto, James, DE BERARDINIS, Ettore, DEL MONTE, Maurizio, Gallucci, Michele, Grompone, Marcello Domenico, Leonardo, Costantino, Panebianco, Valeria, Simone, Giuseppe   +10 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Non-invasive imaging of a choroidal macrovessel

American Journal of Ophthalmology Case Reports, 2020
Purpose: To describe novel anatomic findings of an apparent choroidal macrovessel, originally misdiagnosed as a choroidal tumor, using non-invasive imaging tools.
Oscar Otero-Marquez, Gerardo Ledesma-Gil, Sharmina Alauddin, R. Theodore Smith   +3 more
doaj   +1 more source

Imaging of microwave fields using ultracold atoms [PDF]

, 2010
We report a technique that uses clouds of ultracold atoms as sensitive, tunable, and non-invasive probes for microwave field imaging with micrometer spatial resolution.
Böhm C., Max F. Riedel, Pascal Böhi, Philipp Treutlein, Ramsey N. F., Theodor W. Hänsch   +5 more
core   +2 more sources