Results 121 to 130 of about 10,431,045 (283)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Implementation of theoretical non-photochemical quenching (NPQ(T)) to investigate NPQ of chickpea under drought stress with High-throughput Phenotyping

Scientific Reports
Non-photochemical quenching (NPQ) is a protective mechanism for dissipating excess energy generated during photosynthesis in the form of heat. The accelerated relaxation of the NPQ in fluctuating light can lead to an increase in the yield and dry matter ...
Madita Lauterberg, Henning Tschiersch, Yusheng Zhao, Markus Kuhlmann, Ingo Mücke, Roberto Papa, Elena Bitocchi, Kerstin Neumann   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Phenotyping for Drought Tolerance in Different Wheat Genotypes Using Spectral and Fluorescence Sensors

Plants
The wheat planted at the end of the rainy season in the Cerrado suffers from a strong water deficit. A selection of genetic material with drought tolerance is necessary.
Guilherme Filgueiras Soares, Maria Lucrecia Gerosa Ramos, Luca Felisberto Pereira, Beat Keller, Onno Muller, Cristiane Andrea de Lima, Patricia Carvalho da Silva, Juaci Vitória Malaquias, Jorge Henrique Chagas, Walter Quadros Ribeiro Junior   +9 more
doaj   +1 more source

Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes

npj Precision Oncology
Abstract The epidermis is uniquely exposed to the effects of environmental factors, such as ultraviolet radiation, which induce progressive genetic and epigenetic modifications contributing to aging and the onset of keratinocyte carcinomas.
Rodríguez-Paredes, Manuel, Feng, Yan, Gilliam, Oliver, Wegner, Katrin, Raddatz, Günter, Grönniger, Elke, Lyko, Frank   +6 more
openaire   +3 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Supporting files for "Open-Source Hardware Platform for Automated, Non-Invasive Plant Phenotyping Through Combined RGB and Thermal Imaging"

This dataset is the companion data deposit for the manuscript "Open-Source Hardware Platform for Automated, Non-Invasive Plant Phenotyping Through Combined RGB and Thermal Imaging", currently submitted for peer review.
Bentancor, Marcel
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Leveraging sensor technologies for seed phenotyping by genebanks

Frontiers in Plant Science
Genebanks serve as critical repositories for preserving the genetic diversity of plant species, including crops, forages, and their wild relatives, which is essential for adapting to climate change, enhancing food security, and improving agricultural ...
Kioumars Ghamkhar, David Rousseau
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source