MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report
The Laryngoscope, EarlyView.An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
Veronica Drozdowski‐Nuccio +4 more
wiley +1 more source
Baseline and 24-Hour Changes in the Frontal QRS-T Angle During Non-Invasive Ventilation and Their Association with Clinical Outcomes in Acute Hypercapnic Respiratory Failure. [PDF]
J Clin MedKaramanlıoğlu M +7 more
europepmc +1 more source
A Scoping Review of Laryngeal Edema Rating Scales for Extubated Acute Respiratory Failure Survivors
The Laryngoscope, EarlyView.This scoping review identified existing laryngeal edema rating scales and evaluated whether any are adequately designed for post‐extubation acute respiratory failure (ARF) survivors. Across 35 included studies, most used subjective binary classifications and only the RTOG and Patterson Edema scales had operational definitions and reliability/validity ...
Lalita Sabat +4 more
wiley +1 more source
Efficacy of Non-invasive Ventilation Compared to Intubation in Pediatric Acute Respiratory Failure: A Meta-Analysis. [PDF]
CureusSajid M +9 more
europepmc +1 more source
Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea
The Laryngoscope, EarlyView.A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz +7 more
wiley +1 more source
Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment
Med Research, EarlyView.An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu +9 more
wiley +1 more source
Incidence of nosocomial pneumonia and clinical outcomes of patients requiring non-invasive ventilation: A systematic review and meta-analysis. [PDF]
South Afr J Crit CareSinghal S +7 more
europepmc +1 more source
QQ‐Based Oxygen Extraction Fraction (OEF) Mapping in Mouse Brain: Initial Experience
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Oxygen extraction fraction (OEF) is a vital biomarker of cerebral oxygen metabolism and tissue viability. A novel OEF mapping method, QQ, which combines quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent (qBOLD) (QSM + qBOLD = QQ), has demonstrated promise in detecting disease‐related OEF ...
Quinn Boyer +4 more
wiley +1 more source
Prescription and use of ward-delivered nasal high-flow oxygen and non-invasive ventilation for people with acute respiratory failure. [PDF]
Intern Med JCushnahan A +5 more
europepmc +1 more source