Results 211 to 220 of about 13,157,069 (258)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Topology of varieties with non-isolated singularities

, 2012
openaire   +1 more source

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How to commit concurrent, non-isolated computations

Proceedings of the Fifth IEEE Computer Society Workshop on Future Trends of Distributed Computing Systems, 2002
We face today with the situation that although distributed system are potentially more dependable than centralized systems, they actually confront the users, programmers, and system administrators with more complex and hard to manage failure situations than centralized systems.
Edgar Nett, Michael Mock
openaire   +1 more source

Non-isolated surface singularities

2023
This thesis includes two results about non-isolated complex surface singularities. First, it was recently proved that for finitely determined germs $ Phi: ( C^2, 0) to ( C^3, 0) $, the number $C(Phi)$ of Whitney umbrella points and the number $T(Phi)$ of triple values of a stable deformation are topological invariants.
openaire   +1 more source

A deformation theory for non-isolated singularities

Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg, 1990
With this paper, we get enough knowledge of the deformation theory for non-isolated singularities. The contents are the following: {\S} 1 The functor of admissible deformations (functors for hypersurfaces), {\S} 2 Infinitesimal theory (deformations of \(\Sigma\), the complex D(\(\Sigma\),f)).
De Jong, T., Van Straten, D.
openaire   +2 more sources

Instability of a non-isolated equilibrium

Archive for Rational Mechanics and Analysis, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Non-isolated drop impact on surfaces

Journal of Fluid Mechanics, 2017
Upon impact on a solid surface, a drop expands into a sheet, a corona, which can rebound, stick or splash and fragment into secondary droplets. Previously, focus has been placed on impacts of single drops on surfaces to understand their splash, rebound or spreading.
Y. Wang, L. Bourouiba
openaire   +2 more sources