Results 41 to 50 of about 2,279,157 (279)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

MYH7 mutation and non-isolated noncompaction

Journal of Cardiovascular Surgery and Heart Diseases, 2019
In a recent article, Hirano et al. reported about Ebstein’s anomaly, non-compaction/left ventricular hypertrabeculation (LVHT), and ventricular septal defect (VSD) in a single patient carrying a MYH7 mutation [1]. We have the following comments and concerns.
Josef Finsterer, Claudia Stöllberger
openaire   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Modified Quadratic High-Gain DC–DC Converter for Solar-Powered EV Charging Systems: Simulation, Hardware Prototype, and CHIL-Based Real-Time Validation

IEEE Access
The paper presents a modified design of a quadratic boost DC-DC converter, specially designed for electric vehicle (EV) charging with high voltage gain, low component count, reduced switching stress, and enhanced overall efficiency.
Farha Khan, Hari Om Bansal, Dheerendra Singh   +2 more
doaj   +1 more source

Isolated and non-isolated dark matter halos and the NFW profile

, 2005
We compare the conclusions reached using the coarse-graining technique employed by Henriksen (2004) for a one degree of freedom (per particle) collisionless system, to those presented in a paper by Binney (2004) based on an exact one degree of freedom ...
Henriksen, R. N.
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Study and Design of a Non-Isolated Bidirectional DC-DC Converter Based on a Switched Inductor and Voltage Multiplier Cell for Renewable Energy Applications

Eletrônica de Potência
In this paper, a bidirectional converter with low voltage stress is evaluated. The converter is based on a switched inductor technique combined with a switched capacitor in a voltage multiplier structure, enabling a higher voltage gain while maintaining
Fabiano G. Nimitti, António M. S. S. Andrade   +1 more
doaj   +1 more source

Sarcoidosis Presenting as Isolated Gingival Enlargement: A Rare Case Entity [PDF]

Journal of Clinical and Diagnostic Research, 2014
Sarcoidosis is a non-caseating granulomatous disease . It is a multiorgan inflammatory disorder of unknown etiology. Conditions affecting skin or other organs frequently involve oral cavity and rarely manifest as gingival disease.
Pragya Tripathi, Jaihans Aggarwal, Deepak Chopra, Sukhchain Bagga, Kanika Sethi   +4 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

The L\^e numbers of the square of a function and their applications

, 2005
L\^e numbers were introduced by Massey with the purpose of numerically controlling the topological properties of families of non-isolated hypersurface singularities and describing the topology associated with a function with non-isolated singularities ...
de Bobadilla, Javier Fernández, Gaffney, Terence   +1 more
core   +1 more source