Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PENYELESAIAN PERSAMAAN LINEAR-NON LINEAR DAN PERSAMAAN DIFFERENSIAL DENGAN METODE KESAMAAN [PDF]
Penyelesaian suatu persamaan dalam bentuk persamaan linear, non linear atau persamaan differensial selama ini dapat dilakukan dengan menggunakan rumus atau aturan-aturan yang berbeda bagi semua jenis persamaan. Metode kesamaan merupakan suatu bentuk yang
Abraham, Salusu
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The non-linear normal modes (NNMs) and their bifurcation of a complex two DOF system are investigated systematically in this paper. The coupling and ground springs have both quadratic and cubic non-linearity simultaneously.
Ji, J. +5 more
core +1 more source
Analytical Formulation of the Jacobian Matrix for Non-linear Calculation of the Forced Response of Turbine Blade Assemblies with Wedge Friction Dampers [PDF]
A fundamental issue in turbomachinery design is the dynamical stress assessment of turbine blades. In order to reduce stress peaks in the turbine blades at engine orders corresponding to blade natural frequencies, friction dampers are employed.
Gola M.M +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Group analysis of kinetic equations in a non-linear thermal transport problem
An application of modern group analysis to electron kinetic equations in non-linear thermal transport problem is discussed. The admitted symmetry group is calculated, and the optimal system of one and two-dimensional subalgebras is constructed ...
Meleshko, S. V. +3 more
core +1 more source
A new approach for non-linear analysis of power amplifiers [PDF]
This paper presents a new approach for non-linear analysis of power amplifiers based on the n-order polynomial modelling. A general expression for the fundamental frequency output is developed in this paper.
Budimir, D. +5 more
core +1 more source
Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts
The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell ...
Giuseppe Sancataldo +18 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source

