Results 111 to 120 of about 6,291,274 (347)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Non-linear dynamic analysis of geared systems, part 2 [PDF]

open access: yes
A good understanding of the steady state dynamic behavior of a geared system is required in order to design reliable and quiet transmissions. This study focuses on a system containing a spur gear pair with backlash and periodically time-varying mesh ...
Houser, Donald R.   +2 more
core   +1 more source

Performance Analysis of Non-linear Jacketed CSTR Based on Different Control Strategies [PDF]

open access: yes, 2017
This paper aims at finding the optimum controller for a jacketed Continuous Stirred Tank Reactor (CSTR) under non-ideal conditions. Various conventional control methods show poor response for non-linear processes. This paper outlines the design procedure
Barman, J. K. (Jyoti)   +1 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Flexure Behaviour of Corroded Reinforcement Concrete Beams Under Sustained Loads

open access: yesCivil and Environmental Engineering
The long-term behaviour of concrete beams with corroded reinforcement is a critical aspect that demands thorough comprehension to ensure the serviceability and durability of reinforced concrete structures.
Abed Al-Mortadha O., Daud Sultan A.
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Gait Kinematics of Individuals with SYNGAP1-Related Disorder Compared with Age-Matched Neurotypical Individuals

open access: yesApplied Sciences
SYNGAP1-related disorder is a rare neurodevelopmental disorder characterized by intellectual and motor disabilities, including disordered gait control. Currently, there have been few studies that have assessed the gait of individuals with SYNGAP1-related
Charles S. Layne   +4 more
doaj   +1 more source

Dynamic analysis of space-related linear and non-linear structures [PDF]

open access: yes
In order to be cost effective, space structures must be extremely light weight, and subsequently, very flexible structures. The power system for Space Station Freedom is such a structure. Each array consists of a deployable truss mast and a split blanket
Bosela, Paul A.   +2 more
core   +1 more source

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