Results 271 to 280 of about 6,291,274 (347)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rethinking ratio-based normalization towards model-based approaches in heart weight analysis. [PDF]

Sci Rep
Oestereicher MA, da Silva-Buttkus P, Gailus-Durner V, Marschall S, Fuchs H, IMPC Consortium, Hrabě de Angelis M, Schneltzer E, Spielmann N.   +8 more
europepmc   +1 more source

NON-LINEAR RELATIONSHIP BETWEEN BOND PRICES AND ELECTRICITY PRICES IN INDIA: AN ANALYSIS USING THRESHOLD REGRESSION APPROACH

Robin Thomas
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Interpretable learning of temporal cellular dynamics from single-cell data. [PDF]

Cell Rep Methods
Kouadri Boudjelthia I, Milite S, El Kazwini N, Huang Y, Sottoriva A, Sanguinetti G.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Reduced Mortality with Use of Point of Care Cell Suspension Autograft. [PDF]

J Burn Care Res
Ahmad M, Sen S, Romanowski K, Palmieri T, Greenhalgh DG, Heard J.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Serum 25(OH)D concentration and risk of all-cause and cause-specific mortality in patients with chronic kidney disease: systematic review and dose-response meta-analysis of observational cohort studies. [PDF]

Nutr Metab (Lond)
Hacheso SK, Naghshi S, Kiani S, Amirazad H, Alamdari NM, Farrin N, Yagin NL, Bahrami A, Tutunchi H, Najafipour F.   +9 more
europepmc   +1 more source

Non-linear analysis of heart rate variability and its application to predict hypotension during spinal anesthesia for cesarean delivery

, 2012
Laura Canga, Augusto Navarro, Juan Bolea, José María Remartínez, Pablo Laguna, Raquel Bailón   +5 more
openalex   +1 more source