Results 91 to 100 of about 2,447,517 (340)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Age-Specific Force of Natural Selection and Walls of Death
, 2008 W. D. Hamilton's celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation.
Evans, Steven N. +2 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Current Harmonic Impact on Active Power Losses and Temperature Distribution in Power Cables
EnergiesThe active power losses are dependent on the flowing electric power value through overhead and cable lines. The current flow through the conductor causes negative phenomena to occur, such as released heat.
Natalia Radwan-Pragłowska +3 more
doaj +1 more source
Elastic-Plastic Non Linear Behaviors of Suddenly Loaded Structures [PDF]
American Journal of Engineering and Applied Sciences, 2011 Problem statement: The adaptively shifted integration technique was applied to the elasticplastic analysis of framed structures under dynamic loading. Approach: This study used analysis of linear beam element, the reshifting of the of the integration points in the element is conducted in order to attain higher accuracy.
openaire +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Non-linear analysis of laminated composite doubly curved shallow shells
Vietnam Journal of Mechanics, 2006 This paper deals with governing equations and approximate analytical solutions based on some wellknown assumptions to the non-linear buckling and vibration problems of laminated composite doubly curved shallow shells.
Dao Huy Bich
doaj +1 more source
Non-linear dynamic analysis of geared systems, part 2 [PDF]
A good understanding of the steady state dynamic behavior of a geared system is required in order to design reliable and quiet transmissions. This study focuses on a system containing a spur gear pair with backlash and periodically time-varying mesh ...
Houser, Donald R. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source