Results 91 to 100 of about 13,012,379 (283)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Repeated patterns in tree genetic programming [PDF]
, 2005 We extend our analysis of repetitive patterns found in genetic programming genomes to tree based GP. As in linear GP, repetitive patterns are present in large numbers.
Banzhaf, W., Langdon, W.B.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Calculation of stationary points in linear bilevel programming problems
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 Bilevel programming problems are considerably difficult for numerical analysis. Despite the vast amount of literature and research dedicated to studying them, there are no universal methods to solve them and numerous publications are concerned mainly ...
D. E. Berezhnov, L. I. Minchenko
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Fuzzy Non-Linear Programming for Fuzzy Inventory Model with Storage Space and Budget Constraint
Journal of Computing Research and InnovationWith an emphasis on improving inventory control for a convenience shop in Malaysia, this study explores the use of a fuzzy inventory model in the context of retail management.
Norpah Mahat +1 more
doaj +1 more source
Strict Solution Method for Linear Programming Problem with Ellipsoidal Distributions under Fuzziness [PDF]
, 2009 This paper considers a linear programming problem with ellipsoidal distributions including fuzziness. Since this problem is not well-defined due to randomness and fuzziness, it is hard to solve it directly.
Hasuike, Takashi, Katagiri, Hideki
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source