Results 121 to 130 of about 367,297 (292)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Economic Growth and Extreme Poverty in Sub-Saharan African Countries: Non-Linearity and Governance Threshold Effect. [PDF]

J Knowl Econ, 2023
Saidi Y, Labidi MA, Ochi A.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Economic growth and poverty in sub‑Saharan African countries: non‑linearity and exports threshold effect

Journal of Applied Economics
This study investigates how economic growth translates into poverty reduction in Sub-Saharan Africa (SSA) using NARDL and PSTR models with data from 31 countries (2000–2022).
Faustin Maniraguha, Josine Uwilingiye, Etienne Ndemezo, Charles Ruranga   +3 more
doaj   +1 more source

Non-linearity of Metabolic Pathways Critically Influences the Choice of Machine Learning Model. [PDF]

Front Artif Intell, 2022
Lo-Thong-Viramoutou O, Charton P, Cadet XF, Grondin-Perez B, Saavedra E, Damour C, Cadet F.   +6 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Not straightforward: modelling non-linearity in training load and injury research. [PDF]

BMJ Open Sport Exerc Med, 2021
Bache-Mathiesen LK, Andersen TE, Dalen-Lorentsen T, Clarsen B, Fagerland MW.   +4 more
europepmc   +1 more source

Disentangling non-linearities in the long- and short-run price relationships: An application to the U.S. hog/Pork supply chain [PDF]

Increased concentration at the retail, food processing and farm input manufacturing levels has brought increased attention to patterns in retail-to-farm price spreads.
Gervais, Jean-Philippe
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Study of optical non-linearity from structural perspective in Rhodamine using z-scan technique co-related to luminescence spectroscopy

Results in Chemistry
Molecular structures of dyes differ with substituent and can result in different forms of a dye. For instance, Rhodamine gives Rh 6G, Rh B, Rh 123, Rh 110, etc., with varying properties that depend on the substituent.
Dimishree Neog, Abhijeet Das, Rituraj Mahanta, Subrata Hazarika   +3 more
doaj   +1 more source