Results 241 to 250 of about 360,599 (282)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

The effect of non-linearity of railway tracks on ground-borne vibration

, 2014
Hussein, Mohammed, Koroma, Samuel, Ntotsios, Evangelos, Thompson, David   +3 more
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Non-Linear Vibrations

1986
This book expounds the theory of non-linear vibrations, a topic of great interest at present because of its many applications to important fields in physics and engineering. After introducing chapters giving the basic techniques for the study of non-linear systems the authors develop in detail the theory of selected topics encountered in their own work,
G. Schmidt, A. Tondl
openaire   +1 more source

Tissue non-linearity

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2009
The propagation of acoustic waves is a fundamentally non-linear process, and only waves with infinitesimally small amplitudes may be described by linear expressions. In practice, all ultrasound propagation is associated with a progressive distortion in the acoustic waveform and the generation of frequency harmonics.
openaire   +2 more sources

Non linear Standard Regulators

IFAC Proceedings Volumes, 1990
Abstract The problem of designing Non Linear Standard Regulators (NLSR) is faced for uncertain systems with time delay. Some recent rules for robust tuning of conventional controllers are recalled. The favourable characteristics of the Variable Structure Control (VSC) approach to the design of NLSR for system without delay are shown by a comparison ...
BALESTRINO, ALDO, BRAMBILLA, ALESSANDRO, SCALI, CLAUDIO, LANDI, ALBERTO   +3 more
openaire   +2 more sources

A Non-Linear Filter

Stochastic Analysis and Applications, 2008
Using a measure change related to Bayes' rule recursive estimates are obtained for an approximate conditional density where a state process has deterministic dynamics and it is observed in additive Gaussian noise.
Elliott, R., Leung, H., Deng, J.
openaire   +3 more sources

Non-Linear Confluence Analysis

Theory of Probability & Its Applications, 1957
Non-linear confluence analysis, necessary for the treatment of experimental data when all variables are subject to errors, is considered from the standpoint of the maximum likelihood method. The likelihood function is a product of curvilinear integrals of the respective distribution densities of each point of the curve.
Klepikov, N. P., Sokolov, S. N.
openaire   +2 more sources

Non-linear CT windows

Computerized Radiology, 1987
The display of computerized tomographic (CT) data requires data compression because of the limited shades of grey which the eye can differentiate. This may lead to information loss which can be minimized by a more efficient utilization of the available levels of grey than that afforded by conventional linear windows.
J M, Gomori, I, Steiner
openaire   +2 more sources