Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim+11 more
wiley +1 more source
Formalizing Determinacy of Concurrent Revisions [PDF]
Concurrent revisions is a concurrency control model designed to guarantee determinacy, meaning that the outcomes of programs are uniquely determined. This paper describes an Isabelle/HOL formalization of the model's operational semantics and proof of determinacy.
arxiv
Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew+2 more
wiley +1 more source
Formal Verification of Real-Time Autonomous Robots: An Interdisciplinary Approach. [PDF]
Foughali M, Zuepke A.
europepmc +1 more source
Treatment-control comparisons in platform trials including non-concurrent controls [PDF]
Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to the control arm before the arm enters the trial. The use of non-concurrent controls in the analysis is attractive because it may increase the trial's power of testing ...
arxiv
DGCC:A New Dependency Graph based Concurrency Control Protocol for Multicore Database Systems [PDF]
Multicore CPUs and large memories are increasingly becoming the norm in modern computer systems. However, current database management systems (DBMSs) are generally ineffective in exploiting the parallelism of such systems. In particular, contention can lead to a dramatic fall in performance.
arxiv
This review examines the fluid dynamic behavior within carbonaceous porous structures, linking structural characteristics to electrolyte transport and electrochemical performance. Specifically, it quantitatively assesses the effect of polyphenol derivatives‐harnessed multiscale pore structures on active surface utilization and electrochemical activity ...
Minjun Kim+3 more
wiley +1 more source
Towards Topology-Free Programming for Cyber-Physical Systems with Process-Oriented Paradigm. [PDF]
Zyubin VE+3 more
europepmc +1 more source
Fray: An Efficient General-Purpose Concurrency Testing Platform for the JVM [PDF]
Concurrency bugs are hard to discover and reproduce. Prior work has developed sophisticated algorithms to search for concurrency bugs, such as partial order sampling (POS); however, fundamental limitations with existing platforms for concurrency control hinder effective testing of real-world software.
arxiv
The Impact of Timestamp Granularity in Optimistic Concurrency Control [PDF]
Optimistic concurrency control (OCC) can exploit the strengths of parallel hardware to provide excellent performance for uncontended transactions, and is popular in high-performance in-memory databases and transactional systems. But at high contention levels, OCC is susceptible to frequent aborts, leading to wasted work and degraded performance ...
arxiv