Results 171 to 180 of about 109,513 (348)
Evolving Methods in Genetic Epidemiology. IV. Approaches to Non-Mendelian Inheritance [PDF]
Epidemiologic Reviews, 1997 From this overview it can be concluded that the understanding of the biologic properties and the development of analytic tools to identify repeat sequence mutations, genomic imprinting effects, and mitochondrial mutations are only beginning. Development of approaches to identify such phenomena as modifying effects or genetic components of complex ...
openaire +3 more sources
iLABMED, EarlyView.The expression pathway of COX and the downstream mechanism of PGE. M: muscarinic receptor; PL: phospholipid; PLA2: phospholipase A2; AA: arachidonic acid; EP1: prostaglandin E1 receptor; EP2: prostaglandin E2 receptor; EP3: prostaglandin E3 receptor; EP4: prostaglandin E4 receptor.
Cong Wu +5 more
wiley +1 more source
The role of haplotype complementation and purifying selection in the genome evolution [PDF]
, 2010 We discuss two different ways of chromosomes' and genomes' evolution. Purifying selection dominates in large panmictic populations, where Mendelian law of independent gene assortment is valid. If the populations are small, recombination processes are not
Cebrat, Stanislaw +2 more
core
iMeta, EarlyView.This study identified 10 reliable quantitative trait loci (QTLs) governing cotton resistance to V. dahliae in various environments through a genome‐wide association analysis (GWAS) using an upland cotton population. The pyramid of these 10 elite alleles reduced the disease index of cotton to V. dahliae from 70 to 20.
Xiaojun Zhang +30 more
wiley +1 more source
Drug resistance in idiopathic generalized epilepsies: Evidence and concepts
Epilepsia, Volume 63, Issue 12, Page 3007-3019, December 2022., 2022 Abstract Although approximately 10%–15% of patients with idiopathic generalized epilepsy (IGE)/genetic generalized epilepsy remain drug‐resistant, there is no consensus or established concept regarding the underlying mechanisms and prevalence. This review summarizes the recent data and the current hypotheses on mechanisms that may contribute to drug ...
Joanna Gesche, Christoph P. Beier
wiley +1 more source
Non-Mendelian inheritance of macronuclear mutations is gene specific in Paramecium tetraurelia. [PDF]
, 1994 J Scott +3 more
openalex +1 more source
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies
Epilepsia, Volume 63, Issue 12, Page 3125-3133, December 2022., 2022 Abstract Objective Monogenic epilepsies are rare but often severe. Because of their rarity, they are neglected by traditional drug developers. Hence, many lack effective treatments. Treatments for a disease can be discovered more quickly and economically by computationally predicting drugs that can be repurposed for it.
Basel Taweel +2 more
wiley +1 more source
Regularity inheritance in pseudorandom graphs [PDF]
arXiv, 2016 Advancing the sparse regularity method, we prove one-sided and two-sided regularity inheritance lemmas for subgraphs of bijumbled graphs, improving on results of Conlon, Fox and Zhao [Adv. Math. 256 (2014), 206--290]. These inheritance lemmas also imply improved $H$-counting lemmas for subgraphs of bijumbled graphs, for some $H$.
arxiv
Whole genome sequencing and rare variant analysis in essential tremor families.
PLoS ONE, 2019 Essential tremor (ET) is one of the most common movement disorders. The etiology of ET remains largely unexplained. Whole genome sequencing (WGS) is likely to be of value in understanding a large proportion of ET with Mendelian and complex disease ...
Zagaa Odgerel +6 more
doaj +1 more source
Microsatellite Genotyping of Post-PCR Fluorescently Labeled Markers
BioTechniques, 2000 We show that a post-PCR multicolor fluorescence-labeling technique is applicable to multiplex microsatellite genotyping. Forty-three dinucleotide microsatellite markers, which are located on 11q13-23, a candidate region for dominant familial exudative ...
H. Kondo +4 more
doaj +1 more source