Results 41 to 50 of about 366,231 (255)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Shifting Baselines and the Conservation of Non‐Native Species [PDF]
Conservation Biology, 2014 Peer ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Non-native invasive species and novel ecosystems [PDF]
F1000Prime Reports, 2015 Invasions by non-native species have caused many extinctions and greatly modified many ecosystems and are among the major anthropogenic global changes transforming the earth. Beginning in the mid-1980s, a dramatic burst of research in invasion biology has revealed a plethora of previously unrecognized impacts and laid bare the scope of the phenomenon ...
openaire +2 more sources
Cabomba caroliniana Gray (Cabombaceae) invades major waterways in Belgium
Knowledge and Management of Aquatic Ecosystems, 2019 Recently, unattached viable stem fragments of the invasive macrophyte Cabomba caroliniana Gray were found at several locations in two canals in northern Belgium.
Scheers Kevin +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Non‐native flora of Italy: Species distribution and threats
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 2010 Abstract In this paper, we provide an overview of the distribution and invasive status of non‐native species in the Italian flora across its administrative regions, biogeographic regions and main land use types, and a synthesis of current knowledge on the threats they pose within the country. The information on non‐native plant species collected during
CELESTI, Laura +28 more
openaire +11 more sources
PLoS ONE, 2013 The effects of non-native species invasions on community diversity and biotic homogenization have been described for various taxa in urban environments, but not for land snails.
Michal Horsák +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source