Results 161 to 170 of about 135,346 (336)

Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao   +4 more
wiley   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan   +8 more
wiley   +1 more source

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS. [PDF]

open access: yesNat Protoc, 2023
Johnson JAI   +17 more
europepmc   +1 more source

Genetic Profile and Symptom Pattern Explain Variability of Deep Brain Stimulation Effect in Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Bilateral globus pallidus pars interna deep brain stimulation (GPi‐DBS) is a recognized and effective treatment option for drug‐resistant dystonia patients. However, the clinical GPi‐DBS outcomes vary significantly. Herein, we explored the pre‐implant factors affecting GPi‐DBS effectiveness.
Mahboubeh Ahmadipour   +6 more
wiley   +1 more source

Parsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization. [PDF]

open access: yesNat Commun, 2023
Han S   +13 more
europepmc   +1 more source

Towards a Fairer Non-negative Matrix Factorization

open access: yes
Topic modeling, or more broadly, dimensionality reduction, techniques provide powerful tools for uncovering patterns in large datasets and are widely applied across various domains. We investigate how Non-negative Matrix Factorization (NMF) can introduce bias in the representation of data groups, such as those defined by demographics or protected ...
Kassab, Lara   +5 more
openaire   +2 more sources

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