Results 151 to 160 of about 16,220,352 (310)

Mass models of galaxy clusters from a non-parametric weak-lensing reconstruction

The Open Journal of Astrophysics
We study the CLASH sample of galaxy clusters using a new deprojection method for weak gravitational lensing observations. This method is non-parametric, allowing us to infer mass profiles, or equivalently circular velocities, without having to assume a ...
Tobias Mistele, Federico Lelli, Stacy McGaugh, James Schombert, Benoit Famaey   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Efficient Estimation of Copula-based Semiparametric Markov Models [PDF]

This paper considers efficient estimation of copula-based semiparametric strictly stationary Markov models. These models are characterized by nonparametric invariant (one-dimensional marginal) distributions and parametric bivariate copula functions ...
Yanping Yi, Xiaohong Chen, Wei Biao Wu
core  

Nonparametric and Parametric Modeling of Hydrodynamics for a Fully Appended Autonomous Underwater Vehicle

Journal of Marine Science and Engineering
Hydrodynamic models underpin Autonomous Underwater Vehicle (AUV) design, motion control, and performance evaluation. Existing methods face two critical bottlenecks: (1) conventional explicit CFD requires predefined trajectories, which fails to capture ...
Yingjie Guan, Xiaoyang Deng, Yougang Bian, Xuan Zeng, Xiaojun Zhuo, Xu Liu   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Environmental Efficiency Measurement with Translog Distance Functions: A Parametric Approach [PDF]

We use a flexible parametric hyperbolic distance function to estimate environmental efficiency when some outputs are undesirable. Cuesta and Zofio (J. Prod.
Zofío, José Luis, Cuesta, Rafael A., Knox, C.A.   +2 more
core  

Multivariate Interval-Censored Survival Data: Parametric, Semi-parametric and Non-parametric Models

, 2014
Interval censoring means that an event time is only known to lie in an interval (L,R], with L the last examination time before the event, and R the first after.
Philip Hougaard, Hougaard, Philip
core   +1 more source

Quantile Non‑parametric Additive Models

Acta Universitatis Lodziensis. Folia Oeconomica, 2019
Quantile regression allows us to assess different possible impacts of covariates on different quantiles of a response variable. Additive models for quantile functions provide an attractive framework for non‑parametric regression applications focused on functions of the response instead of its central tendency. Total variation smoothing penalties can be
openaire   +4 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Balancing speed and executability in interactive text-to-CAD code generation for early-stage parametric CAD ideation

Journal of King Saud University: Computer and Information Sciences
The demand for Computer-Aided Design (CAD) in industrial product development continues to grow, motivating a shift from traditional graphical interfaces toward automated parametric modeling workflows that support rapid iteration and interactive ...
Yuhao Sun, Hao Cheng, Shang Zheng, Hualong Yu, Haitao Zou   +4 more
doaj   +1 more source