Results 121 to 130 of about 282,540 (265)
A parametric additive hazard model for time-to-event analysis
BMC Medical Research MethodologyBackground In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, and flexibility.
Dina Voeltz +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Bayesian Semi- and Non-parametric Models for Longitudinal Data with Multiple Membership Effects in R. [PDF]
J Stat Softw, 2014 Savitsky TD, Paddock SM.
europepmc +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
Mass models of galaxy clusters from a non-parametric weak-lensing reconstruction
The Open Journal of AstrophysicsWe study the CLASH sample of galaxy clusters using a new deprojection method for weak gravitational lensing observations. This method is non-parametric, allowing us to infer mass profiles, or equivalently circular velocities, without having to assume a ...
Tobias Mistele +4 more
doaj +1 more source
Insights on synaptic paired-pulse response using parametric and non-parametric models. [PDF]
Annu Int Conf IEEE Eng Med Biol Soc, 2013 Bouteiller JM +5 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Quantile Non‑parametric Additive Models
Acta Universitatis Lodziensis. Folia Oeconomica, 2019 Quantile regression allows us to assess different possible impacts of covariates on different quantiles of a response variable. Additive models for quantile functions provide an attractive framework for non‑parametric regression applications focused on functions of the response instead of its central tendency. Total variation smoothing penalties can be
openaire +4 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source