Results 81 to 90 of about 284,592 (266)
Non-parametric Latent Modeling and Network Clustering [PDF]
, 2020 The paper exposes a non-parametric approach to latent and co-latent modeling of bivariate data, based upon alternating minimization of the Kullback-Leibler divergence (EM algorithm) for complete log-linear models. For categorical data, the iterative algorithm generates a soft clustering of both rows and columns of the contingency table.
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Revista Colombiana de Estadística, 2007 Our goal is to model, with forecasting aims, the daily electricity demand in a southeast colombian region through a non-parametric regression model implementation. We consider some “calendar variables” such as time of the day, day of the week, month, and
Barrientos Andrés Felipe +2 more
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Geosystems and GeoenvironmentClimate change is considered a long-term change in precipitation, temperature and other meteorological variables. The pattern of meteorological variables is changing due to anthropogenic activities globally. Climate change has posed threat to natural and
Md Masroor, Haroon Sajjad
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Correlated Non-Parametric Latent Feature Models
CoRR, 2012 Appears in Proceedings of the Twenty-Fifth Conference on Uncertainty in Artificial Intelligence (UAI2009)
Finale Doshi-Velez, Zoubin Ghahramani
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source