Results 91 to 100 of about 979,711 (299)

Bootstrapping spectral statistics in high dimensions [PDF]

, 2019
Statistics derived from the eigenvalues of sample covariance matrices are called spectral statistics, and they play a central role in multivariate testing.
Aue, Alexander, Blandino, Andrew, Lopes, Miles   +2 more
core   +1 more source

Semi-Parametric Empirical Best Prediction for small area estimation of unemployment indicators

, 2018
The Italian National Institute for Statistics regularly provides estimates of unemployment indicators using data from the Labor Force Survey. However, direct estimates of unemployment incidence cannot be released for Local Labor Market Areas.
Alfo', Marco, Marino, Maria Francesca, Ranalli, Maria Giovanna, Salvati, Nicola   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Testing for cointegration using induced-order statistics. [PDF]

In this paper we explore the usefulness of induced-order statistics in the characterization of integrated series and of cointegration relationships. We propose a non-parametric test statistic for testing the null hypothesis of two independent random ...
Escribano, Álvaro, Santos, T., Sipols, Ana E.   +2 more
core  

Semiparametric estimation of spectral density function for irregular spatial data [PDF]

, 2015
Estimation of the covariance structure of spatial processes is of fundamental importance in spatial statistics. In the literature, several non-parametric and semi-parametric methods have been developed to estimate the covariance structure based on the ...
Yang, Shu, Zhu, Zhengyuan, Zhu, Zhengyuan   +2 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Adaptabilidade e estabilidade fenotípica de genótipos de cana-de-açúcar no estado de Minas Gerais Adaptability and phenotypic stability of sugarcane genotypes in the state of Minas Gerais

Ciência Rural, 2012
O objetivo deste trabalho foi avaliar a adaptabilidade e estabilidade fenotípica de genótipos de cana-de-açúcar no estado de Minas Gerais. Foram avaliados 15 genótipos em nove ambientes.
Luís Cláudio Inácio da Silveira, Volmir Kist, Thiago Otávio Mendes de Paula, Márcio Henrique Pereira Barbosa, Ricardo Augusto de Oliveira, Edelclaiton Daros   +5 more
doaj   +1 more source

Storage and retrieval of ultrafast single photons using a room-temperature diamond quantum memory

, 2014
We report the storage and retrieval of single photons, via a quantum memory, in the optical phonons of room-temperature bulk diamond. The THz-bandwidth heralded photons are generated by spontaneous parametric downconversion and mapped to phonons via a ...
Bustard, Philip J., England, Duncan G., Fisher, Kent A. G., Lausten, Rune, MacLean, Jean-Philippe W., Resch, Kevin J., Sussman, Benjamin J.   +6 more
core   +1 more source