Results 21 to 30 of about 2,751,336 (281)

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Statistics of quantum transmission in one dimension with broad disorder

, 2007
We study the statistics of quantum transmission through a one-dimensional disordered system modelled by a sequence of independent scattering units. Each unit is characterized by its length and by its action, which is proportional to the logarithm of the ...
Abrahams E, Cox D R, Cox D R, Crisanti A, D Boosé, Gnedenko B V, Gradshteyn I S, Hughes B D, J M Luck, Kramer B, Lifshitz I M, Luck J M, Luck J M, Lévy P, Metzler R, Shlesinger M F   +15 more
core   +2 more sources

Robust Model-based Inference for Non-Probability Samples

, 2022
With the ubiquitous availability of unstructured data, growing attention is paid as how to adjust for selection bias in such non-probability samples. The majority of the robust estimators proposed by prior literature are either fully or partially design-based, which may lead to inefficient estimates if outlying (pseudo-)weights are present. In addition,
Rafei, Ali, Elliott, Michael R., Flannagan, Carol A. C.   +2 more
openaire   +2 more sources

Kernel Weighting for blending probability and non-probability survey samples

SORT, 2023
In this paper we review some methods proposed in the literature for combining a nonprobability and a probability sample with the purpose of obtaining an estimator with a smaller bias and standard error than the estimators that can be obtained using only the probability sample. We propose a new methodology based on the kernel weighting method.
Rueda, María del Mar, Cobo, Beatriz, Rueda-Sánchez, Jorge Luis, Ferri-García, Ramon, Castro-Martín, Luis   +4 more
openaire   +6 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Gravity Dual for a Model of Perception

, 2011
One of the salient features of human perception is its invariance under dilatation in addition to the Euclidean group, but its non-invariance under special conformal transformation.
Bialek, Bialek, Coleman, d’Agostini, Gubser, Ho, Ho, Hull, Mueck, Nakayama, Nakayama, Nakayama, Polchinski, Riva, Wiskott, Witten, Yu Nakayama, Zamolodchikov   +17 more
core   +1 more source

On free stochastic processes and their derivatives [PDF]

, 2013
We study a family of free stochastic processes whose covariance kernels $K$ may be derived as a transform of a tempered measure $\sigma$. These processes arise, for example, in consideration non-commutative analysis involving free probability.
Alpay, Daniel, Jorgensen, Palle, Salomon, Guy   +2 more
core   +3 more sources