Results 71 to 80 of about 2,911,013 (294)

Joining Forces of Bayesian and Frequentist Methodology: A Study for Inference in the Presence of Non-Identifiability

open access: yes, 2012
Increasingly complex applications involve large datasets in combination with non-linear and high dimensional mathematical models. In this context, statistical inference is a challenging issue that calls for pragmatic approaches that take advantage of ...
Box GEP   +4 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Multi-overlap simulations of spin glasses [PDF]

open access: yes, 2001
We present results of recent high-statistics Monte Carlo simulations of the Edwards-Anderson Ising spin-glass model in three and four dimensions. The study is based on a non-Boltzmann sampling technique, the multi-overlap algorithm which is specifically ...
Alain Billoire   +7 more
core   +4 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Recognize nuance when interpreting monitoring results

open access: yesMethods in Ecology and Evolution
We recently published a study discussing the pitfalls of non‐probability sampling when selecting monitoring sites. We demonstrated that selecting sites based on abundance can often lead to biased inference, and we suggested that researchers use ...
Christopher J. W. McClure   +1 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

EWOM EFFECT ON INTENTION TO VISIT RAJA AMPAT PAPUA (Theory of Planned Behavior) [PDF]

open access: yes, 2017
This study aims to determine the effect of eWOM and intention to travel to Raja Ampat Papua using the approach of theory of planned behavior. This study uses quantitative data.
Kusumawardhany, Prita Ayu   +2 more
core  

A Gibbs sampler on the $n$-simplex

open access: yes, 2014
We determine the mixing time of a simple Gibbs sampler on the unit simplex, confirming a conjecture of Aldous. The upper bound is based on a two-step coupling, where the first step is a simple contraction argument and the second step is a non-Markovian ...
Smith, Aaron
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Comparing the costs and detectability of bobcat using scat‐detecting dog and remote camera surveys in central Wisconsin

open access: yesWildlife Society Bulletin, 2015
Determining cost‐effective field methods for detecting carnivores is critical for effective survey and monitoring studies. As the bobcat (Lynx rufus) undergoes range expansion in the northern and eastern United States, field methods may be useful for ...
John D. J. Clare   +3 more
doaj   +1 more source

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