Results 111 to 120 of about 487,224 (310)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Non-profit organisations and the Internet
First Monday, 1999 The Internet is the fastest growing communications medium in the world. While some individuals and companies have been quick to capitalise on this medium, non-profit organisations have been slower on the uptake. However with a decline in the level of donations from traditional donors who are aging and a shift by their children away from their parent's ...
openaire +2 more sources
Public provision of a private good: What is the point of the BSD license? [PDF]
Software is a potentially excludable public good. It is possible, at some cost, to exclude non-paying users from its consumption by using copyright law or technological restraints.
Alex Gaudeul
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
İnternetin En Büyük Kütüphanesi: The Internet Archive
Türk Kütüphaneciliği, 2014 The biggest library of the internet: The Internet Archive The Internet Archive is a non-profit organisation that was founded to build an Internet library.
Remzi Salihoğlu
doaj
Exclusion of Migrant Workers from National UHC Systems-Perspectives from HealthServe, a Non-profit Organisation in Singapore. [PDF]
Asian Bioeth Rev, 2020 Rajaraman N, Yip TW, Kuan BYH, Lim JFY.
europepmc +1 more source
Virtuous Circles: New Expressions of Collective Philanthropy in Asia [PDF]
, 2014 This is the third paper of the Entrepeneurial Social Finance in Asia series, and it addresses the Giving Circles, its importance and their context in Asia." The theme of entrepreneurial philanthropy focused largely on the practices of venture ...
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Environment, difficulty and consequences of the implementation of a total quality management system [PDF]
, 2002 .Matia Fundazioa, organización sin ánimo de lucro, desde una visión humanista e integral de la persona mayor, presta servicios sociosanitarios desde 1888, y aborda desde comienzos de 1998 la mejora continua de su organización.
Isabel Genua, María
core