Results 51 to 60 of about 270,616 (305)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Features of the relationship of adolescents’ self-esteem and their attitude to the teacher

Развитие образования
The article discusses the problem of the relationship between self-esteem of adolescents and their attitude towards the school teacher. The self-esteem of adolescents is connected with the formation of their active cognitive activity, which serves as a ...
Olga N. Bakaeva, Olga V. Anufrieva, Olga V. Ryzhkova   +2 more
doaj   +1 more source

Exploratory machine learning analysis to characterize angioscopic features associated with atherosclerosis-related aortic dissection: an exploratory single-center angioscopic study

Frontiers in Cardiovascular Medicine
AimAortic dissection (AD) is a life-threatening condition. Non-obstructive general angioscopy (NOGA) enables direct visualization of spontaneously ruptured aortic plaques and injuries (SRAPIs).
Satoru Takahashi, Sei Komatsu, Sei Komatsu, Chikao Yutani, Chikao Yutani, Hiroyuki Nishi, Hiroyuki Nishi, Yoshiharu Higuchi, Yoshiharu Higuchi, Nobuzo Iwa, Tomoki Ohara, Tomoki Ohara, Mitsuhiko Takewa, Kazuhisa Kodama, Kazuhisa Kodama   +14 more
doaj   +1 more source

The Potential of the Internet for Non-Profit Organizations

First Monday, 2002
This paper examines the concept of a digital divide faced by third sector organizations. It introduces problematic examples of Internet use by non-profits, identifies characteristics defining their involvement in the digital world and analyzes models of technology access that suggest significant potential benefit.
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

“Clash of Civilizations” Concept in the EU Right-Wing Populists’ Discourse

RUDN Journal of Political Science, 2019
The concept of “clash of civilizations”, proposed by S. Huntington in the early 1990s, has been controversial, yet has found a solid following, primarily among the right side of the political spectrum in Europe and the US. Since such humanitarian aspects
Stanislav O. Byshok
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source