Results 161 to 170 of about 12,220,401 (374)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Joining the Non-Proliferation Treaty
, 2018 List of contributors Introduction (Yoko Iwama) Part I 1. Nuclear Proliferation and Conceptions of National Interest: The U.S. Case, 1960-1967 (William Burr) 2. After the Hegemony of the "Atoms for Peace" Programmeme: Multilateral Non-proliferation Policy under the Nixon and Ford Administrations (Shinsuke TOMOTSUGU) Part II 3.
openaire +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Fossil Fuel Non-Proliferation Treaty: what it is, its importance for health, and why Australia should endorse it. [PDF]
Med J AustColagiuri P +3 more
europepmc +1 more source
The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation [PDF]
, 2016 Biao Yang +3 more
openalex +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Potential applications of microbial genomics in nuclear non-proliferation. [PDF]
Front MicrobiolMacGregor H +4 more
europepmc +1 more source
Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells [PDF]
, 2016 Ting Li +5 more
openalex +1 more source