Results 141 to 150 of about 29,450 (234)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, Volume 16, Issue 6, Page 1150-1165, June 2026.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Optimized Deep Learning Framework for Diabetic Retinopathy Based on Systematic Multi‐Stage Transfer Learning and Predictive Risk Stratification

open access: yesApplied AI Letters, Volume 7, Issue 2, June 2026.
A multi‐stage transfer learning framework systematically optimizes CNN architectures for diabetic retinopathy detection and risk stratification from fundus images. EfficientNetB7 achieves 96% accuracy while a survival‐inspired model generates continuous risk scores aligned with DR severity for clinically meaningful patient risk assessment.
Mujidat Jibrin, Abdsamad Benkrid
wiley   +1 more source

Retinopathy among type 2 diabetic patients seen at a tertiary hospital in Nigeria: a preliminary report

open access: yes, 2008
Adeyinka Ashaye1, Ayodeji Arije2, Modupe Kuti3, Bolutife Olusanya1, Ezekiel Ayeni1, Adesoji Fasanmade4, Kehinde Akinlade3, Millicent Obajimi5, Jokotade Adeleye41Ophthalmology Department, College of Medicine, University of Ibadan, Nigeria; 2Renal Unit ...
Adeyinka Ashaye   +5 more
core  

Characteristics Analysis of Multifocal Electroretinogram in Non-proliferative Diabetic Retinopathy

open access: yes
Abstract Purpose To investigate multifocal electroretinogram (mfERG) changes in non-proliferative diabetic retinopathy (NPDR) patients compared to normal people, and to clarify the differences in changes across various regions of the retina. Methods We selected 18 healthy individuals (22 eyes) and 26 NPDR patients (45 eyes), using the RETscan
Ziwei Li, Yan Cui
openaire   +1 more source

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