Results 171 to 180 of about 29,450 (234)

RORA Targeting PRNP Modulates Age‐Related Cataract via Activation Oxidative Injury‐Induced Cellular Senescence and Apoptosis of Lens Epithelial Cells

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Yue Zou   +11 more
wiley   +1 more source

Cost‐Effectiveness of Automated Insulin Delivery Systems in Paediatrics, T1D and T2D Adults Across Four Nordic Countries

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4784-4794, June 2026.
ABSTRACT Aims This study evaluated long‐term cost‐effectiveness of automated insulin delivery (AID) systems versus multiple daily injections (MDI) + CGM in children with type 1 diabetes (T1D), adults with T1D and insulin‐treated individuals with type 2 diabetes (T2D) across Denmark, Finland, Norway and Sweden.
Johan Jendle   +5 more
wiley   +1 more source

Cost‐effectiveness analysis comparing real‐time continuous glucose monitoring with self‐monitoring of blood glucose for patients with type 2 diabetes treated with insulin in Japan

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 6, Page 989-999, June 2026.
ABSTRACT Introduction Real‐time continuous glucose monitoring (rt‐CGM) systems are associated with reductions in glycated hemoglobin (HbA1c) and hypoglycemic events compared with self‐monitoring of blood glucose (SMBG). This analysis aimed to assess the cost‐effectiveness of rt‐CGM compared with SMBG in the management of people with T2D who require ...
Hirotaka Watada   +6 more
wiley   +1 more source

Associations of retinal neurovascular dysfunction with inner retinal layer thickness in non-proliferative diabetic retinopathy. [PDF]

open access: yesGraefes Arch Clin Exp Ophthalmol
Pemp B   +6 more
europepmc   +1 more source

Clinical Diabetic Peripheral Neuropathy: Can It Be Reversed? Arguments for and Against From a NEUROdiab Debate

open access: yesJournal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Diabetic peripheral neuropathy (DPN) is a prevalent and disabling complication of diabetes, yet whether established clinical DPN is reversible remains debated. At the 35th Annual Meeting of NEUROdiab, a formal debate examined arguments ‘for’ and ‘against’ the proposition that clinical DPN can be reversed.
Gordon Sloan   +9 more
wiley   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

open access: yesThe Journal of Physiology, Volume 604, Issue 11, Page 4247-4260, 1 June 2026.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott   +6 more
wiley   +1 more source

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