Results 101 to 110 of about 382,729 (291)

Modelling of Dynamic Strain Aging with a Dislocation-Based Isotropic Hardening Model and Investigation of Orthogonal Loading [PDF]

, 2008
Based on experimental results, a dislocation material model describing the dynamic strain aging\ud effect at different temperatures is presented. One and two stage loading tests were performed in\ud order to investigate the influence of the loading ...
Berisha, B., Hora, P., Tong, L., van den Boogaard, Antonius H., Wahlen, A., Yang, D.Y.   +5 more
core   +2 more sources

A plasticity model with yield surface distortion for non proportional loading [PDF]

International Journal of Plasticity, 2001
In order to enhance the modeling of metallic materials behavior in non proportional loadings, a modification of the classical elastic-plastic models including distortion of the yield surface is proposed. The new yield criterion uses the same norm as in the classical von Mises based criteria, and a "distorted stress" Sd replacing the usual stress ...
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dynamics of Large-Scale Plastic Deformation and the Necking Instability in Amorphous Solids

, 2002
We use the shear transformation zone (STZ) theory of dynamic plasticity to study the necking instability in a two-dimensional strip of amorphous solid. Our Eulerian description of large-scale deformation allows us to follow the instability far into the ...
A. E. Lobkovsky, G. Gagnon, J. Aboudi, J. Lubliner, J. S. Langer, J. S. Langer, J. S. Langer, J. S. Langer, J. W. Hutchinson, L. O. Eastgate, L. Pechenik, L. Pechenik, L. E. Malvern, M. L. Falk, M. L. Falk, P. N. Brown, R. M. McMeeking, V. Tvergaard   +17 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Loading of a cold atomic beam into a magnetic guide

, 2002
We demonstrate experimentally the continuous and pulsed loading of a slow and cold atomic beam into a magnetic guide. The slow beam is produced using a vapor loaded laser trap, which ensures two-dimensional magneto-optical trapping, as well as cooling by
Aclan, A., Cren, P., Dalibard, J., Guéry-Odelin, D., Roos, C. F.   +4 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Comparison of different seismic non-linear analyses of an ancient masonry building [PDF]

, 2009
This paper presents a study about the possibilities of non-linear static analyses for evaluating the seismic performance of ancient masonry buildings. The adopted case study is a Portuguese typology of the 19th century.
Lourenço, Paulo B., Mendes, N.
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Fatigue Testing and Evaluation of Fatigue Strength under Multiaxial Stress State; Why do we need fatigue testing?

MATEC Web of Conferences, 2018
Types of multiaxial fatigue tests and their experimental results are presented in this paper. There are typical three types in multiaxial fatigue tests: the combining push-pull and reversed torsion loading test using hollow cylinder specimen, the biaxial
Itoh Takamoto, Ogawa Fumio, Morishita Takahiro   +2 more
doaj   +1 more source