Results 101 to 110 of about 147,595 (279)

Equivalent static wind loads for structures with non-proportional damping [PDF]

, 2013
In current practice, wind structural design is often carried out using the concept of equivalent static wind loads. The main characteristic of such loadings is to reproduce, with static analyses, the same extreme structural responses as those resulting from a formal buffeting analysis.
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Modeling of Multi-Axial Fatigue Damage Under Non-Proportional Variable-Amplitude Loading Conditions [PDF]

, 2017
This dissertation presents a new path-dependent non-proportional multi-axial fatigue model which is formulated in an incremental form of moment of load path (MLP) on σ-√β τ plane, ε-√(β^ε ) γ plane or K plane (i.e K_I-√(β^K ) K_III plane), depending upon
Mei, Jifa
core  

Ductile Damage Evolution under Non-Proportional Loading

Journal of Japan Society of Civil Engineers, Ser. A2 (Applied Mechanics (AM)), 2017
Fincato R, Tsutsumi S
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Investigation of fretting fatigue behaviour under multiaxial non-proportional loading

, 2011
Fretting fatigue is a structural mechanism observed when two contacting bodies are subjected to an oscillatory loading. The study on fretting fatigue behaviour of 60Si2Mn steel was conducted under condition of multiaxial non-proportional loading.
X Jiang, G He, M Zhu, B Liu
core   +1 more source

Fatigue crack growth under non-proportional loading

, 2021
134
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stamina of a non-gasketed flange joint under combined internal pressure, axial and bending loading : an experimental study

, 2009
The performance of a bolted flange joint is characterized mainly by its 'strength' and 'sealing capability'. A number of numerical and experimental studies have been conducted to study these characteristics under internal pressure loading conditions alone.
Abid, Muhammad, Nash, David
core   +1 more source