Validation of non-REM sleep stage decoding from resting state fMRI using linear support vector machines [PDF]
, 2016 A growing body of literature suggests that changes in consciousness are reflected in specific connectivity patterns of the brain as obtained from resting state fMRI (rs-fMRI). As simultaneous electroencephalography (EEG) is often unavailable, decoding of
Altmann, A +9 more
core +1 more source
Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies
Animal Models and Experimental Medicine, EarlyView.This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang +4 more
wiley +1 more source
Sleep and vigilance linked to melanism in wild barn owls. [PDF]
, 2014 Understanding the function of variation in sleep requires studies in the natural ecological conditions in which sleep evolved. Sleep has an impact on individual performance and hence may integrate the costs and benefits of investing in processes that are
Dreiss, A.N. +4 more
core +1 more source
Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism
Annals of Neurology, EarlyView.Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono +5 more
wiley +1 more source
REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity [PDF]
, 1990 Nine healthy male subjects were deprived of REM sleep during the first 5 h after sleep onset. Afterwards recovery sleep was undisturbed. During the deprivation period the non-REM EEG power spectrum was reduced when compared to baseline for the ...
Achermann +22 more
core +4 more sources
Diffusion MRI and α‐Synuclein Seed Amplification Status in Parkinson's Disease
Annals of Neurology, EarlyView.Objective Positive α‐synuclein seed amplification assay (SAA) is a biomarker found in most people with Parkinson's disease (PD). We explored if free‐water (FW) imaging detects microstructural differences in the brains of patients with early PD with SAA+ or SAA– status.
Shannon Y. Chiu +145 more
wiley +1 more source
Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep
eLife, 2016 Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (REM) sleep and arousal. Using transgenic mice in which channelrhdopsin-2 is selectively expressed in cholinergic neurons, we show ...
Kun-Ming Ni +9 more
doaj +1 more source
An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control. [PDF]
, 2019 The perioculomotor (pIII) region of the midbrain was postulated as a sleep-regulating center in the 1890s but largely neglected in subsequent studies.
Barger, Zeke +10 more
core
Hyperarousal captured in increased number of arousal events during pre-REM periods in individuals with frequent nightmares [PDF]
, 2019 The aim of this study was to investigate hyperarousal in individuals with frequent nightmares (NM participants) by calculating arousal events during nocturnal sleep.
Blaskovich, Borbala +4 more
core +1 more source
The Anatomical Record, EarlyView.Abstract A recent debate has emerged between Caspar et al. (2024) and Herculano‐Houzel (2023) on inferring extinct dinosaur cognition by estimating brain neuron counts. While thought‐provoking, the discussion largely overlooks the function of cognition, as well as partly neglects the difficulties involved in estimating neuron numbers, which according ...
Thomas Rejsenhus Jensen +7 more
wiley +1 more source