Results 161 to 170 of about 1,511,239 (338)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

NDTMS Themed Report NDTMS themed report: Patterns of mortality amongst injecting and non-injecting drug users in contact with treatment services in the North West of England, 2003/04-2005/06

, 2007
Ayesha Hurst, Caryl Beynon, Sara Jane Helen Hughes, Adam Marr, Jim McVeigh   +4 more
openalex   +1 more source

Valuing PSS outputs and quality changes

, 2006
The Gershon review of efficiency recommended that target improvements in efficiency should be met both through financial savings and through improvements in quality of outputs.
Burge, Peter, Gallo, Frederico, Netten, Ann   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Studies on the non-transplanting cultivation of sweet potato on hillside farm (Report. 1)

, 1953
Kyoichi Matsuoka, Masahiro Kawakami
openalex   +2 more sources

Large non-coronary sinus of Valsalva aneurysm: a case report of an unusual cause of angina pectoris [PDF]

, 2020
Hidehiro Iwakawa, Takako Iino, Hiroshi Yamamoto, Hiroyuki Watanabe   +3 more
openalex   +1 more source

Young or Old Age and Non‐White Race Are Associated With Poor Patient‐Reported Outcome Measure Response Compliance After Orthopaedic Surgery [PDF]

, 2023
Benjamin Levens, B.S. Kim, Nicholas Aksu, C. Scott Dorris, Steven J. Svoboda, Wiemi A. Douoguih, James C. Dreese   +6 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Non-referral of unnatural deaths to coroners and non-reporting of unnatural deaths on death certificates in Taiwan: implications of using mortality data to monitor quality and safety in healthcare [PDF]

, 2008
Tsung‐Hsueh Lu, Kai‐Ping Shaw, Pei-Yuen Hsu, L.-H. Chen, S.-M. Huang   +4 more
openalex   +1 more source