Results 111 to 120 of about 392,427 (260)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

(Re)producing Identities: The Assumptions in (non)Identity-Affecting Debates

Humana.Mente: Journal of Philosophical Studies
Advances in procreative technologies can entail changes on a number of levels: changing scientific realities but also changing ethical considerations, and changes to the concepts they use or assumptions that some ethical arguments rely upon.
Oliver Feeney, Sergei Shevchenko, Vojin Rakić   +2 more
doaj  

Risk Factors of Co‏ronary Artery Disease in Residents and Non-Resid Entsof Elderly Care Homes in Tehran

Sālmand, 2011
Objectives: Cardiovascular disease is the leading cause of death in United States and many parts of the world. This study aimed to evaluate the risk factors of coronary artery disease in residents and non-residents of elderly care homes in Tehran ...
Afzal Shamsi
doaj  

Grandparenting after parental divorce: The association between non-resident parent-child meetings and grandparenting in Italy. [PDF]

Eur J Ageing, 2018
Albertini M, Tosi M.
europepmc   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Determinants of Unpaid Hospital Charges Among Non-Resident Foreign Patients: A Retrospective Single-Center Study in Tokyo, Japan. [PDF]

Healthcare (Basel)
Saeki S, Nakamura Y, Miki N, Osanai Y, Horikawa M, Hinohara C.   +5 more
europepmc   +1 more source

The HIV care continuum among resident and non-resident populations found in venues in East Africa cross-border areas. [PDF]

J Int AIDS Soc, 2019
Edwards JK, Arimi P, Ssengooba F, Mulholland G, Markiewicz M, Bukusi EA, Orikiiriza JT, Virkud A, Weir S.   +8 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Paternity success for resident and non-resident males and their influences on paternal sibling cohorts in Japanese macaques (Macaca fuscata) on Shodoshima Island. [PDF]

PLoS One
Ishizuka S, Inoue E, Kaji Y.
europepmc   +1 more source