Results 191 to 200 of about 859,493 (314)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Water Quality Modeling: Terrain Analysis and the Agricultural Non-Point Source Pollution (AGNPS) Model

, 1991
Water Resources Research CenterWater Resources Research Center. (1991). Water Quality Modeling: Terrain Analysis and the Agricultural Non-Point Source Pollution (AGNPS) Model.
Water Resources Research Center
core  

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Non-conventional water resources in coastal areas: a review of the use of reclaimed water

, 2004
In an era of increasing concern for limited water resources a wise joint management of conventional and nonconventional water resources must be considered.
Tapias Pantebre, Josefina Carlota, Salgot i de Marçay, Miquel, Tapias Pantebre, Josefina C., Salgot de Marçay, Miquel, Tapias, Josefina C.   +4 more
core   +1 more source

Valuing conservation and natural wealth: The blue economy of manta ray watching in the Maldives. [PDF]

PLoS One
Moloney HM, Rojas MIG, Rothe N, Armstrong AO, Ballard K, Barraud F, Hamdan F, Richardson AJ, Riyad EM, Sawers TJ, Townsend KA, Stevens GMW.   +11 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Water loss management in Blantyre - Malawi

, 2010
Water loss in the distribution system is a common problem in Malawi, like in other developing countries worldwide. Blantyre Water Board BWB), established in 1929 under the name Mudi Water Works, the oldest water board in Malawi, is faced with this ...
Kafodya, V.J.
core  

Pyrolysis behavior of <i>Sterculia guttata</i> shell biomass: kinetics, thermodynamics, techno-economic and life cycle assessment of industrial-scale biochar production. [PDF]

RSC Adv
Sivaraman S, Selvasembian R.
europepmc   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, EarlyView.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

Expanding budget space to improve health outcomes in low- and middle-income countries: what role for tax expenditures? [PDF]

Health Policy Plan
Tagem AME, Tapsoba Y, Barroy H.
europepmc   +1 more source