Results 181 to 190 of about 121,857 (258)

Evaluation of Therapeutic Opioids in Skin‐Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair

open access: yesDrug Testing and Analysis, EarlyView.
Concentration ranges, dose–concentration relationships, and metabolite‐to‐parent drug ratios of therapeutic opioids were evaluated in hair and skin swab samples of 150 pediatric patients. Skin‐derived matrices such as sweat or sebum were shown to contribute to analyte incorporation into hair in a systematic manner.
Max Polke   +7 more
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin   +5 more
wiley   +1 more source

Virtual Reality Externalization (VR‐E) for Patients With Eating Disorders: A Pilot Study

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Despite significant health and psychosocial impairments, many individuals with eating disorders (ED) view their disorder as an integral part of their identity. Because this “ego‐syntonicity” is associated with low treatment motivation and treatment dropouts, we investigated the acceptability, feasibility, and effects of a newly ...
Samuel P. E. Mehranfar   +4 more
wiley   +1 more source

Long‐term cardiovascular outcomes of immune checkpoint inhibitor‐related myocarditis: A large single‐centre analysis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1237-1245, April 2025.
Abstract Aims Immune checkpoint inhibitors (ICI) are the cornerstone of modern oncology; however, side effects such as ICI‐related myocarditis (irM) can be fatal. Recently, Bonaca proposed criteria for irM; however, it is unknown if they correlate well with cardiovascular (CV) ICI‐related adverse events.
Lorenzo Braghieri   +12 more
wiley   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber   +7 more
wiley   +1 more source

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