Results 71 to 80 of about 121,857 (258)

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Short-term Benefits of Mobilization for Patients with Non- Specific Neck Pains: Executive Function and Neck Pain Intensity

Journal of International Academy of Physical Therapy Research, 2019
Background: Cervical mobilization has been applied mainly for the improvement of arm and neck movements and pain reduction, and little research has been done to improve the executive function. Since this kind of so-called mechanical neck pain is one of most common symptoms, there are controversial issues about this with spine alignment. Posteroanterior
Wansuk Choi, Seoyoon Heo
openaire   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Functional Improvement in Patients with Non-Specific Neck Pain: A Meta-Analysis of Muscle Energy Technique and Proprioceptive Neuromuscular Facilitation

Allied Medical Research Journal
Background: Neck pain is a common musculoskeletal disorder with significant societal and individual consequences. Proprioceptive Neuromuscular Facilitation (PNF) and Muscle Energy Technique (MET) are two physical therapy techniques that have shown ...
Qurat-ul-Ain Ahmad, Syed Abid Mehdi Kazmi, Sagar Kumar, Faisal Ali Khan   +3 more
doaj  

Effectiveness of Thoracic Manipulation on the Treatment of Patients With Mechanical Non-Specific Neck Pain

Journal of Modern Rehabilitation, 2017
Introduction: Non-specific mechanical neck pain is a common musculoskeletal complaint that is generally treated conservatively using electro/thermal therapeutic agents, exercise, soft tissue techniques, and manual therapy.
Maryam Abbaszadeh-Amirdehi, Setareh Mirasi, Hadi Salehi, Gholamreza Olyaei   +3 more
doaj   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Effectiveness of Cervical Mobilization and Cervical Traction in Management of Non Specific Neck Pain

Journal Riphah College of Rehabilitation Sciences, 2015
Background: Neck pain is described as the pain perceived anywhere between superior nucal line & first thoracic vertebrae. About 60% of the subjects are likely to develop the chronic nature of neck pain if it's not managed promptly.
Hamid Ali, Rashid Hafeez Nasir, Danish Hassan   +2 more
doaj  

TO COMPARE THE EFFECTIVENESS OF TWO DIFFERENT TECHNIQUES IN IMPROVING NON-SPECIFIC NECK PAIN, ROM AND DISABILITY IN PATIENT WITH NON-SPECIFIC NECK PAIN

International Journal of Advanced Research
Background: The neck pain is a common cause of disability and health problem in the general population. It can be caused by the stress over the musculoskeletal system due to postural disorders and may also be associated with other causes such as inter vertebral disc herniation, nerve compression, or fracture.According to reports, the prevalence of neck
Kavita a, Preeti Devi, Jyoti b
openaire   +1 more source