Results 241 to 250 of about 12,832,564 (302)

Understanding Risks in the Care of People With Dementia in Acute Hospital Settings: Definitions, Types and Management Strategies—A Scoping Review

open access: yesJournal of Clinical Nursing, Volume 35, Issue 11, Page 4708-4724, November 2026.
ABSTRACT Aims This scoping review explores how risk is defined, managed and mitigated in the care of people with dementia in acute hospital settings. Methods This scoping review followed Arksesy and O'Malley's five‐stage framework (2005) and was guided by the Joanna Briggs Institute methodology.
Ashitha Bhaskaran   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, Volume 16, Issue 10, Page 1958-1973, October 2026.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan   +17 more
wiley   +1 more source

Exosomal let‐7c‐5p From AMI Patient Plasma Modulates Neuronal PANoptosis via ZBP1 In Vitro

open access: yesCell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Acute myocardial infarction (AMI) significantly elevates the risk of ischemic stroke (IS), yet the molecular mechanisms linking cardiac and cerebral injury remain unclear. Emerging evidence highlights the role of circulating exosomes in mediating inter‐organ communication via microRNAs (miRNAs). In this study, plasma exosomes from AMI patients
Zhiyong Zhang   +11 more
wiley   +1 more source

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