Results 191 to 200 of about 26,546,882 (300)

Social networks as pathways of political mobility in Portuguese governments. [PDF]

PLoS One
Borges R, Shaul C, Pinheiro FL, Damásio B.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Same actors, same processes, same outcomes: Global health architecture reform or restoration? [PDF]

PLOS Glob Public Health
Kantiana ID, Alpeza F, Bandara S, Cook AR, Rahman-Shepherd A.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Structural imbalance in youth weight management policies in China: a three-dimensional analysis of school responsibility and collaborative support. [PDF]

Front Public Health
Zhang Y, Wang X.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Two decades of majoritarian hegemony and minority subordination within Indonesian religious governance amidst polarization. [PDF]

Front Sociol
Andhita PR, Novianti E, Sumartias S, Rahmat A.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Civil society resistance to anti-rights mobilisation.

BMJ
McGovern T, Meng A, O'Rourke M, Athar R.
europepmc   +1 more source

Silence, sacrifice, and subordination: Unpacking the gendered migration narratives of policy actors in Malaysia. [PDF]

Asian Pac Migr J
Foley L.
europepmc   +1 more source