Results 111 to 120 of about 1,974,822 (284)

Non-Steady State NMR Effect and Application on Time-Varying Magnetic Field Measurement. [PDF]

Sensors (Basel), 2022
Zeng X, Ma H, Jin J, Zhang H, Ma J.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analysis of transitional stresses in non-local thermo-elastic disc under steady state temperature

International Journal of Applied Mechanics and Engineering
In solid mechanics, there are various applications of non-local theories in wave propagation, size effects, surface effects, and understanding interactions of composite materials.
Praveen Ailawalia, Ajay Bhiwal, Jatinder Kaur, Paweł Jurczak   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mathematical analysis of batch reactor performance for the enzymatic synthesis of cephalexin: Laplace Homotopy perturbation method and Adomian decomposition method

Partial Differential Equations in Applied Mathematics
In this article, a mathematical model of diffusion reaction in kinetically controlled cephalexin synthesis in the batch reactor with penicillin acylase immobilized in glyoxyl-agarose is analyzed. The kinetic model is a non-linear non-stead-state reaction–
M. Mallikarjuna, R. Senthamarai
doaj   +1 more source

Non-Steady-State Fickian Diffusion Models Decrease the Estimated Gel Layer Diffusion Coefficient Uncertainty for Diffusive Gradients in Thin-Films Passive Samplers. [PDF]

Environ Sci Technol, 2023
Hodges SD, Wahman DG, Haupert LM, Pham HT, Bozarth MK, Howland MB, Fairey JL.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Symmetries, conservation laws and entanglement in non-Hermitian fermionic lattices

SciPost Physics
Non-Hermitian quantum many-body systems feature steady-state entanglement transitions driven by the competition between unitary dynamics and dissipation.
Rafael D. Soares, Youenn Le Gal, Chun Y. Leung, Dganit Meidan, Alessandro Romito, Marco Schirò
doaj   +1 more source

Applying the indicator amino acid oxidation technique in the domestic cat: results of a pilot study and development of a non-steady state prediction model. [PDF]

J Anim Sci, 2023
Pezzali JG, Rafii M, Courtney-Martin G, Cant JP, Shoveller AK.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source