Results 161 to 170 of about 1,942,248 (284)

Computing the Accuracy of Complex Non-Random Sampling Methods: The Case of the Bank of Canada's Business Outlook Survey [PDF]

A number of central banks publish their own business conditions survey based on non-random sampling methods. The results of these surveys influence monetary policy decisions and thus affect expectations in financial markets.
David Dupuis, Daniel de Munnik, Mark Illing   +2 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Algorithm dependence of patient phenotypes in Long COVID: a patient-led, multi-method clustering of 6031 patients using 162 self-reported symptoms. [PDF]

Oxf Open Immunol
Green TD, McWilliams C, de Figueiredo L, Soares L, Pollack B, Cohen AK, Zhi-Xuan T, Falor T, Davis HE.   +8 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An Exploration of Machine Learning Methods in Human Biomonitoring. [PDF]

Int J Environ Res Public Health
Singh K, Bi J, Musende M, Collins SP, Borghese MM, Hu JMY, Pollock T, St-Amand A, Hennessy D, Buckeridge DL.   +9 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Severity and management of postabortion complications in Kenya: results from a nationally representative cross-sectional survey. [PDF]

BMJ Glob Health
Giorgio M, Juma K, Wado YD, Owolabi O, Rich C, Akuku I, Mutuku E, Giuffrida M, Athero S, Mueke S.   +9 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Traditional or Modern Contraception? Association Between Health Worker Contact and Contraceptive Choice in India: Findings From NFHS 2019-2021. [PDF]

Stud Fam Plann
Bhan N, Johns N, Hay K, Patwardhan V, Singh A, Ambast S, McDougal L.   +6 more
europepmc   +1 more source

How to prove similarity a precongruence in non-deterministic call-by-need lambda calculi

, 2006
Extending the method of Howe, we establish a large class of untyped higher-order calculi, in particular such with call-by-need evaluation, where similarity, also called applicative simulation, can be used as a proof tool for showing contextual preorder ...
Mann, Matthias, Schmidt-Schauß, Manfred
core