Results 11 to 20 of about 49,076 (222)

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Off-axis Afterglow Closure Relations and Fermi-LAT Detected Gamma-Ray Bursts

The Astrophysical Journal, 2023
Gamma-ray bursts (GRBs) are one of the most promising transient events for studying multiwavelength observations in extreme conditions. Observation of GeV photons from bursts would provide crucial information on GRB physics, including the off-axis ...
N. Fraija, M. G. Dainotti, D. Levine, B. Betancourt Kamenetskaia, A. Galvan-Gamez   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

GRB 221009A: Observations with LST-1 of CTAO and Implications for Structured Jets in Long Gamma-Ray Bursts

The Astrophysical Journal Letters
GRB 221009A is the brightest gamma-ray burst (GRB) observed to date. Extensive observations of its afterglow emission across the electromagnetic spectrum were performed, providing the first strong evidence of a jet with a nontrivial angular structure in ...
K. Abe, S. Abe, A. Abhishek, F. Acero, A. Aguasca-Cabot, I. Agudo, C. Alispach, D. Ambrosino, F. Ambrosino, L. A. Antonelli, C. Aramo, A. Arbet-Engels, C. Arcaro, T. T. H. Arnesen, K. Asano, P. Aubert, A. Baktash, M. Balbo, A. Bamba, A. Baquero Larriva, U. Barres de Almeida, J. A. Barrio, L. Barrios Jiménez, I. Batkovic, J. Baxter, J. Becerra González, E. Bernardini, J. Bernete, A. Berti, I. Bezshyiko, C. Bigongiari, E. Bissaldi, O. Blanch, G. Bonnoli, P. Bordas, G. Borkowski, G. Brunelli, A. Bulgarelli, M. Bunse, I. Burelli, L. Burmistrov, M. Cardillo, S. Caroff, A. Carosi, R. Carraro, M. S. Carrasco, F. Cassol, D. Cerasole, G. Ceribella, A. Cerviño Cortínez, Y. Chai, K. Cheng, A. Chiavassa, M. Chikawa, G. Chon, L. Chytka, G. M. Cicciari, A. Cifuentes, J. L. Contreras, J. Cortina, H. Costantini, M. Dalchenko, P. Da Vela, F. Dazzi, A. De Angelis, M. de Bony de Lavergne, R. Del Burgo, C. Delgado, J. Delgado Mengual, M. Dellaiera, D. della Volpe, B. De Lotto, L. Del Peral, R. de Menezes, G. De Palma, C. Díaz, A. Di Piano, F. Di Pierro, R. Di Tria, L. Di Venere, R. M. Dominik, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, L. Eisenberger, D. Elsässer, G. Emery, J. Escudero, V. Fallah Ramazani, F. Ferrarotto, A. Fiasson, L. Foffano, F. Frías García-Lago, S. Fröse, Y. Fukazawa, S. Gallozzi, R. Garcia López, S. Garcia Soto, C. Gasbarra, D. Gasparrini, D. Geyer, J. Giesbrecht Paiva, N. Giglietto, F. Giordano, N. Godinovic, T. Gradetzke, R. Grau, D. Green, J. Green, S. Gunji, P. Günther, J. Hackfeld, D. Hadasch, A. Hahn, M. Hashizume, T. Hassan, K. Hayashi, L. Heckmann, M. Heller, J. Herrera Llorente, K. Hirotani, D. Hoffmann, D. Horns, J. Houles, M. Hrabovsky, D. Hrupec, D. Hui, M. Iarlori, R. Imazawa, T. Inada, Y. Inome, S. Inoue, K. Ioka, M. Iori, T. Itokawa, A. Iuliano, J. Jahanvi, I. Jimenez Martinez, J. Jimenez Quiles, I. Jorge Rodrigo, J. Jurysek, M. Kagaya, O. Kalashev, V. Karas, H. Katagiri, D. Kerszberg, T. Kiyomot, Y. Kobayashi, K. Kohri, A. Kong, P. Kornecki, H. Kubo, J. Kushida, B. Lacave, M. Lainez, G. Lamanna, A. Lamastra, L. Lemoigne, M. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, J. Lozano Bahilo, F. Lucarelli, H. Luciani, P. L. Luque-Escamilla, P. Majumdar, M. Makariev, M. Mallamaci, D. Mandat, M. Manganaro, D. K. Maniadakis, G. Manicò, K. Mannheim, S. Marchesi, F. Marini, M. Mariotti, P. Marquez, G. Marsella, J. Martí, O. Martinez, G. Martínez, M. Martínez, A. Mas-Aguilar, M. Massa, G. Maurin, D. Mazin, J. Méndez-Gallego, S. Menon, E. Mestre Guillen, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, M. Mizote, T. Mizuno, M. Molero Gonzalez, E. Molina, T. Montaruli, A. Moralejo, D. Morcuende, A. Moreno Ramos, A. Morselli, V. Moya, H. Muraishi, K. Murase, S. Nagataki, T. Nakamori, A. Neronov, D. Nieto Castaño, M. Nievas Rosillo, L. Nikolic, K. Nishijima, K. Noda, D. Nosek, V. Novotny, S. Nozaki, M. Ohishi, Y. Ohtani, T. Oka, A. Okumura, R. Orito, L. Orsini, J. Otero-Santos, P. Ottanelli, M. Palatiello, G. Panebianco, D. Paneque, F. R. Pantaleo, R. Paoletti, J. M. Paredes, M. Pech, M. Pecimotika, M. Peresano, F. Pfeifle, E. Pietropaolo, M. Pihet, G. Pirola, C. Plard, F. Podobnik, M. Polo, E. Prandini, M. Prouza, S. Rainò, R. Rando, W. Rhode, M. Ribó, V. Rizi, G. Rodriguez Fernandez, M. D. Rodríguez Frías, P. Romano, A. Roy, A. Ruina, E. Ruiz-Velasco, T. Saito, S. Sakurai, D. A. Sanchez, H. Sano, T. Šarić, Y. Sato, F. G. Saturni, V. Savchenko, F. Schiavone, B. Schleicher, F. Schmuckermaier, J. L. Schubert, F. Schussler, T. Schweizer, M. Seglar Arroyo, T. Siegert, G. Silvestri, A. Simongini, J. Sitarek, V. Sliusar, A. Stamerra, J. Strišković, M. Strzys, Y. Suda, A. Sunny, H. Tajima, M. Takahashi, J. Takata, R. Takeishi, P. H. T. Tam, S. J. Tanaka, D. Tateishi, T. Tavernier, P. Temnikov, Y. Terada, K. Terauchi, T. Terzic, M. Teshima, M. Tluczykont, F. Tokanai, T. Tomura, D. F. Torres, F. Tramonti, P. Travnicek, G. Tripodo, A. Tutone, M. Vacula, J. van Scherpenberg, M. Vázquez Acosta, S. Ventura, S. Vercellone, G. Verna, I. Viale, A. Vigliano, C. F. Vigorito, E. Visentin, V. Vitale, V. Voitsekhovskyi, G. Voutsinas, I. Vovk, T. Vuillaume, R. Walter, L. Wan, M. Will, J. Wójtowicz, T. Yamamoto, R. Yamazaki, Y. Yao, P. K. H. Yeung, T. Yoshida, T. Yoshikoshi, W. Zhang, (The CTAO-LST Collaboration)   +331 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Low-energy Radio Bursts from Magnetar XTE J1810−197: Implications for Fast Radio Bursts

The Astrophysical Journal
Magnetars are the leading candidate sources of fast radio bursts (FRBs). However, the observational probes of the connections between magnetars and FRBs are severely limited by the paucity of detection of highly energetic radio events from magnetars—to ...
Banshi Lal, Yogesh Maan, Moaz Abdelmaguid, Visweshwar Ram Marthi, Joseph D. Gelfand, Samayra Straal   +5 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source