Results 111 to 120 of about 62,431 (265)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Ecological momentary assessment of the stress-recovery process through technology mHealth in sports: a scoping review. [PDF]

BMC Sports Sci Med Rehabil
Guillen Cots J, Capdevila L, Losilla JM, Parrado E.   +3 more
europepmc   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Analysis of Intellectual Property Rights Reforms Among Health Care Professionals. [PDF]

F1000Res
Gupta VK, Pai Khot AJ, Mishra G, Kumar S, Malhotra S, Arif K, Bhatia S, Rajput A, Almalki SA, Gowdar IM.   +9 more
europepmc   +1 more source

Acoustic Branding, Non-Traditional Trademarks and the Graphical Representation Requirement: A Conceptual and Empirical Analysis

, 2019
Considers the growing range of sound-based stimuli found in multisensory marketing and branding in Hong Kong and Singapore, whether the criteria formulated in Shield Mark BV v Kist (t/a Memex) (C-283/01) (ECJ) for establishing the registrability of acoustic trade marks are now insufficient, and whether the two jurisdictions should introduce a more ...
Lim, Eugene C, Samtani, Anil
openaire   +1 more source

The protection of geographical indications (GI): generating empirical evidence at country and product level to support African ACP country engagement in the Doha round negotiations : peer review of the study and the methodology [PDF]

, 2011
Chabrol, Didier, Marie-Vivien, Delphine
core  

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Enhanced multi-scale trademark element detection using the improved DETR. [PDF]

Sci Rep
Li L, Wang X, Yan WQ.
europepmc   +1 more source

Masters of Their Domains: Trademark Holders Now Have New Ways to Control Their Marks in Cyberspace [PDF]

, 2000
Blasbalg, Gregory B.
core   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source