Results 51 to 60 of about 645,178 (305)

Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes

open access: yesBiophysical Journal, 1994
The intracellular calcium ([Ca2+]i) transient in adult rat heart cells was examined using the fluorescent calcium indicator fluo-3 and a laser scanning confocal microscope. We find that the electrically evoked [Ca2+]i transient does not rise at a uniform rate at all points within the cell during the [Ca2+]i transient. These spatial non-uniformities in [
Cannell, M.B., Cheng, H., Lederer, W.J.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Non-uniform dispersion of the source-sink relationship alters wavefront curvature. [PDF]

open access: yesPLoS ONE, 2013
The distribution of cellular source-sink relationships plays an important role in cardiac propagation. It can lead to conduction slowing and block as well as wave fractionation.
Lucia Romero   +3 more
doaj   +1 more source

Unusual spin-wave population in nickel after femtosecond laser pulse excitation

open access: yes, 2010
The spin-wave relaxation mechanisms after intense laser excitation in ferromagnetic nickel films are investigated with all-optical pump-probe experiments. Uniform precession (Kittel mode), Damon-Eshbach surface modes and perpendicular standing spin waves
Eilers, Gerrit   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

A spatially uniform illumination source for widefield multi-spectral optical microscopy.

open access: yesPLoS ONE, 2023
Illumination uniformity is a critical parameter for excitation and data extraction quality in widefield biological imaging applications. However, typical imaging systems suffer from spatial and spectral non-uniformity due to non-ideal optical elements ...
İris Çelebi   +2 more
doaj   +1 more source

In-plane dissipation as a possible synchronization mechanism for terahertz radiation from intrinsic Josephson junctions of layered superconductors

open access: yes, 2012
Strong terahertz radiation from mesa structure of $\rm{Bi_2Sr_2CaCu_2O_{8+\delta}}$ single crystal has been observed recently, where the mesa intrinsically forms a cavity.
Hu, Xiao, Lin, Shi-Zeng
core   +1 more source

Experimental analysis of structure response to non-uniform support excitation

open access: yesZbornik radova (Građevinski fakultet Sveučilišta u Rijeci), 2018
U seizmički aktivim područjima dugačke konstrukcije s velikom udaljenosti između oslonaca ili osloncima na podlogama različitih geoloških osobina mogu biti pod utjecajem različite seizmičke pobude na svaki od oslonaca. Posljedica toga može biti oštećenje ili otkazivanje sklopa konstukcije uslijed relativnih pomaka oslonaca.
Čeh, Nina, Jelenić, Gordan
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Stator Design Method in Rotor–Stator Interference Flow Fields in Order to Suppress the Vibration of Bladed Disks

open access: yesApplied Sciences, 2022
Based on the computation and analysis of three-dimensional unsteady flow induced by rotor/stator interactions, the characteristics of flow excitation towards bladed disks were studied, including frequency components and circumferential wave components ...
Haoran Ma, Zhou Zhou, Lin Li
doaj   +1 more source

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