Results 51 to 60 of about 187,835 (306)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Violence and Non-Violence at Rock Concerts: 1970s French Society Confronted With Its Contradictions

open access: yesCriminocorpus, 2019
“The hopefulness of ‘Love Power’ has gone out the window,” Michel Lancelot wrote in 1971, adding that “just about everywhere, the revolt is armed” (Campus, 1971). The author was describing the state of violence on American campuses, comparing it with the
Joann Élart
doaj   +1 more source

“True, Masculine Men Are Not Like Women!”: Salafism between Extremism and Democracy

open access: yesReligions, 2020
Whether we should understand Salafism in general as a security threat, as extremist, and as un-democratic and of concern to authorities is a debated question.
Susanne Olsson
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Violence et non-violence dans les concerts rock ou la société française des années 1970 face à ses contradictions

open access: yesCriminocorpus, 2018
“The hopefulness of ‘Love Power’ has gone out the window,” Michel Lancelot wrote in 1971, adding that “just about everywhere, the revolt is armed” (Campus, 1971). The author was describing the state of violence on American campuses, comparing it with the
Joann Élart
doaj   +1 more source

Animalismo e non violenza. L’incidenza della lezione gandhiana sul pensiero di Tom Regan

open access: yesRelations, 2020
In opposition to the anthropocentric model of domination, in Gandhi as in Regan there is the full recovery of an ethical-philosophical tradition based on the model of kinship or fraternity and that insists on the possibility of extending the rules of ...
Luisella Battaglia
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Three Styles in the Study of Violence [PDF]

open access: yes, 2008
This is a postprint (accepted manuscript) version of the article published in Reviews in Anthropology 37:1-19. The final version of the article can be found at http://dx.doi.org/10.1080/00938150701829525 (login required to access content).
Abel Theodore   +18 more
core   +1 more source

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