Results 51 to 60 of about 438,729 (259)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Further Reflections on Samuel P. Huntington’s “Clash of Civilization” and Contemporary Global Politics

Arụmarụka, 2022
When civilizations clash or encounter one another, it is a general expectation that one of them will necessarily influence or even dominate the other. This has been the principal character of the advent of Euro-Western civilizations across regions of the
Damilola Peter Olatade
doaj   +2 more sources

Migration, translation, and transformation of western urban planning models

City, Territory and Architecture, 2020
People, ideas, lifestyles, cultures, architecture and urban planning models have invariably traversed the world as a consequence of military compulsions, political goals, commercial motivations, or aspirational values.
Pilar Maria Guerrieri
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Science and Technology in Non‐Western Cultures

Zygon, 1999
Seline's edited volume relevates non‐Western interaction between religious and scientific domains of human intellectual history. Middle Eastern, South Asian, and Chinese thinkers have played central roles in pursuing intellectual inquiry into topics of ...
doaj   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Palbociclib in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer: A Systematic Scoping Review of Real-World Evidence from Countries Outside of Western Regions that Are Underrepresented in Clinical Trials

Oncology and Therapy
Introduction Limited awareness exists regarding real-world data (RWD) for palbociclib in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced/metastatic breast cancer in populations from certain countries ...
Amit Rauthan, Ankita Jain, Manmohan Singh, Mehmet A. N. Sendur   +3 more
doaj   +1 more source

The antinomian framework of Western and non-Western democracies—from theory to application

Frontiers in Political Science
This article argues in favour of broadening the classical paradigm of democracy that historically emerged in the West. Without disregarding the undiminished significance of the idea of liberal democracy and its deep commitment to universal human rights ...
Oliver Fernando Hidalgo
doaj   +1 more source

Scope of Mutual Transformation of Western and Non-Western Civilizations in Foucault’s Analysis

Journal of Islamic Thought and Civilization, 2011
Both Hegel and Marx believe that non-Western world is not the natural part of dialectical process as non-Western cultures don‘t seem to take part in the process of historical development. So, the only way to turn the nonWestern as Western and vice versa
Dr. Zulfiqar Ali
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source