Results 131 to 140 of about 1,274,147 (339)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Analysis of parametric vibrations of a tensioned string using non-contact measurement methods

open access: yesTechnical Transactions
This paper presents the results of an experimental study of the parametric vibrations of a pulsating tensioned string. At certain amplitudes and frequencies of excitation in the form of a variable axial force, dynamic instability arises in the system ...
Czerwiński Andrzej
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Analysing trends of climatic variables in Purulia district, India using non-parametric methods

open access: yesDiscover Geoscience
Location-specific data on rainfall and temperature trends at different temporal scale is crucial for developing agricultural strategies and managing water resources in drought prone areas like Purulia, West Bengal.
Srija Das, Mary Tahir
doaj   +1 more source

Bednets, Information and Malaria in Orissa [PDF]

open access: yes
This paper studies the identification and estimation of a basic model of technology adoption using specifcally collected information on subjective beliefs and expectations to identify key model parameters.
Alessandro Tarozzi   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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