Results 111 to 120 of about 105,114 (302)

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Patient‐derived organoid‐immune co‐cultures integrated with multi‐omics reveal immunotherapy resistance mechanisms in urothelial carcinoma

iMeta, EarlyView.
Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the exploration of its role in immune checkpoint inhibitor (ICI) resistance remains scarce, thus impeding a deeper understanding of the tumor immune microenvironment
Shan Jiang, Yuxuan Song, Yun Peng, Ran Yan, Yunze Niu, Baoqiang Chen, Jiaxing Lin, Jilin Wu, Shixiang Wang, Yiqing Du, Caipeng Qin, Yihan Lin, Tao Xu   +12 more
wiley   +1 more source

Publisher Correction: Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results

Scientific Reports, 2022
Maryam Kazemi, Mina Bazyar, Mohammad Mehdi Naghizadeh, Azizallah Dehghan, Massih Sedigh Rahimabadi, Mahsa Rostami Chijan, Mostafa Bijani, Maryam Zahmatkeshan, Alireza Ghaemi, Nastaran Samimi, Reza Homayounfar, Mojtaba Farjam   +11 more
doaj   +1 more source

Tackling food marketing to children in a digital world: trans-disciplinary perspectives. Children’s rights, evidence of impact, methodological challenges, regulatory options and policy implications for the WHO European Region [PDF]

, 2016
There is unequivocal evidence that childhood obesity is influenced by marketing of foods and non-alcoholic beverages high in saturated fat, salt and/or free sugars (HFSS), and a core recommendation of the WHO Commission on Ending Childhood Obesity is to ...
Boyland, Emma, Breda, Joao, Handsley, Elizabeth, Jewell, Jo, Tatlow-Golden, Mimi, World Health Organization Regional Office for Europe,, Zalnieriute, Monika   +6 more
core  

Non‐Nutritive Artificial Sweeteners Aspartame and Acesulfame‐K Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease in Male Ldlr−/− Mice

iNew Medicine, EarlyView.
ABSTRACT Aspartame and acesulfame‐K are commonly used non‐nutritive artificial sweeteners, but their impacts on cardiovascular disease and metabolic dysfunction‐associated fatty liver disease (MASLD) are unclear. In this study, we evaluated the impacts of aspartame and acesulfame‐K on MASLD and atherosclerosis in male Ldlr−/− mice fed an AMLN diet ...
Jingjing Xu, Xiaohua Jiang, Jianping Weng, Suowen Xu   +3 more
wiley   +1 more source

Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes

Journal of Periodontology, EarlyView.
Abstract Background This post hoc analysis of the Periodontitis and Coronary Heart Disease study (ClinicalTrials.gov Identifier: NCT01045070) aimed to determine the association between diabetes and recurrent cardiovascular events (CVEs) in patients with cardiovascular disease (CVD) and severe periodontitis.
Stefan Reichert, Axel Schlitt, Selina Rehm, Susanne Schulz   +3 more
wiley   +1 more source

Association between periodontitis and oral health–related quality of life in patients with systemic conditions: A meta‐analysis

Journal of Periodontology, EarlyView.
Abstract Background The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health–related quality of life (OHRQoL) in adults with systemic conditions. Methods Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical ...
Rafael Vargas Bortolaso, Catiusse Crestani Del' Agnese, Leandro Machado Oliveira, Patricia A. Miguez, Fabricio Batistin Zanatta, Raquel Pippi Antoniazzi   +5 more
wiley   +1 more source

Alveolar Fibroblasts Respond to Pseudomonas Aeruginosa Infection With Cytokine Secretion: Role in Acute Lung Inflammation

Med Research, EarlyView.
ABSTRACT Alveolar fibroblasts play a key role in regulation of lung inflammation. Pseudomonas aeruginosa (PAO) is one of the most common pathogens causing lung injury, and the role of PAO‐infected alveolar fibroblasts in such a condition remains unclear.
Yue Zhou, Yangyang Xiao, Wei Liu, Xiaozhi Wang, Tao Wang, Qian Qi, Dong Zhang   +6 more
wiley   +1 more source

Noncommunicable disease research

International Journal of Noncommunicable Diseases, 2016
Research is an essential component of the fight against noncommunicable disease (NCD) as it provides the evidence for effective prevention and control interventions. While the biological causes and manifestations of NCDs have been studied in depth, we are still trying to understand the best ways of implementing effective control policies.
openaire   +2 more sources

Impact of a low‐carbohydrate diet on cardiometabolic parameters in individuals with and without diabetes: An 8‐year longitudinal study within the ELSA‐Brasil cohort

Nutrition in Clinical Practice, EarlyView.
Abstract Background Low‐carbohydrate diets (LCDs) are widely adopted for metabolic management, but their long‐term cardiometabolic effects in diverse populations remain unclear. We aimed to evaluate the association between self‐selected moderate LCD adherence and cardiometabolic parameters in individuals with and without diabetes.
Leticia Batista de Azevedo, Haysla Xavier Martins, Oscar Geovanny Enriquez‐Martinez, Maria del Carmen Bisi Molina   +3 more
wiley   +1 more source