Roadblocks to translational challenges on viral pathogenesis. [PDF]
, 2013 Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven +4 more
core +1 more source
Novel Multiplexed HIV/Simian Immunodeficiency Virus Antibody Detection Assay
Emerging Infectious Diseases, 2011 Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected ...
Steve Ahuka-Mundeke +12 more
doaj +1 more source
Nature Communications, 2021 Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-21 ...
Justin Harper +17 more
doaj +1 more source
Seroprevalence of Zika virus in wild African green monkeys and baboons [PDF]
, 2017 Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined,
Adam L. Bailey +14 more
core +3 more sources
Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis [PDF]
, 2007 The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the decapeptide gonadotropin-releasing hormone (GnRH).
Sabine Heger +56 more
core +1 more source
Ex-vivo expansion of nonhuman primate CD34+ cells by stem cell factor Sall4B
Stem Cell Research & Therapy, 2016 Background Hematopoietic CD34+ stem cells are widely used in the clinical therapy of complicated blood diseases. Stem cell factor Sall4B is a zinc finger transcription factor that plays a vital role in hematopoietic stem cell expansion.
Bin Shen +4 more
doaj +1 more source
Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates
Emerging Infectious Diseases, 2017 The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care.
Ronald B. Reisler +12 more
doaj +1 more source
A comprehensive atlas of white matter tracts in the chimpanzee.
PLoS Biology, 2020 Chimpanzees (Pan troglodytes) are, along with bonobos, humans' closest living relatives. The advent of diffusion MRI tractography in recent years has allowed a resurgence of comparative neuroanatomical studies in humans and other primate species. Here we
Katherine L Bryant +3 more
doaj +1 more source
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation. [PDF]
, 2019 Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders.
Bauman, Melissa D +8 more
core +2 more sources
Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model. [PDF]
Magn Reson MedABSTRACT Purpose Dorsal rhizotomy, or spinal dorsal nerve root lesioning, is a surgical procedure used to treat intractable nerve pain by selectively severing sensory afferent nerve roots. This study aimed to evaluate whether multiparametric MRI, including diffusion tensor imaging (DTI), quantitative magnetization transfer (qMT), chemical exchange ...
Wang F, Gore JC, Chen LM.
europepmc +2 more sources