Results 41 to 50 of about 7,125 (291)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Catalogue of analytical solutions for consolidation of unsaturated soils subjected to various initial conditions and time-dependent loadings [PDF]
, 2016 University of Technology Sydney. Faculty of Engineering and Information Technology.Soil consolidation has been a primary geotechnical interest for decades.
Ho, Huu Liem
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Frontiers in Environmental Science, 2022 Land subsidence is an important environmental problem in the North China Plain (NCP). A typical subsidence area mainly located on adjoining areas of Beijing and Hebei provinces was selected to study the consolidation characteristics of deep clayey soil ...
Fengjunnan Liu +11 more
doaj +1 more source
, 2012 Permeability controls the fluid flow into and out of soft tissue, and plays an important role in maintaining the health status of such tissue. Accurate determination of the parameters that define permeability is important for the interpretation of models
Philip E. Riches, Riches, Philip
core +1 more source
Evaluating Wireless Carrier Consolidation Using Semiparametric Demand Estimation [PDF]
The US mobile phone service industry has dramatically consolidated over the last two decades. One justification for consolidation is that merged firms can provide consumers with larger coverage areas at lower costs. We estimate the willingness to pay for
Jeremy T. Fox +2 more
core +2 more sources
Yantu gongcheng xuebao, 2022 Dewatering and metal removal of silt can be obtained by applying electrokinetics. A coupled model for one-dimensional electroosmosis consolidation and ion migration, called ECT1, is proposed.
ZHOU Ya-dong 1, 2, ZHAI Xin-dong 1, YANG Wen-qing 1
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source