Results 31 to 40 of about 49,489 (261)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

When Nonlinear Differential Equations are Equivalent to Linear Differential Equations [PDF]

SIAM Journal on Applied Mathematics, 1982
A necessary and sufficient condition is established for the existence of a 1-1 transformation of a system of nonlinear differential equations to a system of linear equations. The obtained theorems enable one to construct such transformations from the invariance groups of differential equations.
Kumei, Sukeyuki, Bluman, George W.
openaire   +2 more sources

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Piecewise continuous approach to nonlinear differential equations approximation problem of computational structural mechanics

MATEC Web of Conferences, 2018
This paper presents a nonlinear differential equations system piecewise continuous approximation. The piecewise continuous approximation improves piecewise linear approximation through reducing the errors at the boundaries of different linear ...
Leibov Roman
doaj   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

The Spectral Homotopy Analysis Method Extended to Systems of Partial Differential Equations

Abstract and Applied Analysis, 2014
The spectral homotopy analysis method is extended to solutions of systems of nonlinear partial differential equations. The SHAM has previously been successfully used to find solutions of nonlinear ordinary differential equations.
S. S. Motsa, F. G. Awad, Z. G. Makukula, P. Sibanda   +3 more
doaj   +1 more source

Fuzzy Differential Equations for Nonlinear System Modeling With Bernstein Neural Networks

IEEE Access, 2016
With the fuzzy set theory, the uncertainty of nonlinear systems can be modeled using fuzzy differential equations. The solutions of these equations are the model output, but they are very difficult to obtain.
Raheleh Jafari, Wen Yu, Xiaoou Li
doaj   +1 more source

Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters

Arthritis Care &Research, EarlyView.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US‐based skin assessments for their face validity (differentiation between involved SSc and healthy
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

Jacobi Elliptic Solutions for Nonlinear Differential Difference Equations in Mathematical Physics

Journal of Applied Mathematics, 2012
We put a direct new method to construct the rational Jacobi elliptic solutions for nonlinear differential difference equations which may be called the rational Jacobi elliptic functions method.
Khaled A. Gepreel, A. R. Shehata
doaj   +1 more source